Role of Misu (NSun2) in healthy tissues and tumourigenesis

许多成人组织由干细胞维持。未能控制干细胞的产生或分化成其后代有助于癌症。因此，该项目的目标是确定通过调节干细胞生长和分化来控制健康皮肤维持的关键调节因子和机制。一旦我们确定了调节干细胞命运的重要因素，我们将进一步研究它们的错误调节是否会导致癌症。这些方法正在开发和利用，以揭示参与癌症发展的新机制和途径，并可能导致发现新的抗癌药物靶点。

Many adult tissues are maintained by stem cells. Failure to control the generation of stem cells or the differentiation into their progeny contribute to cancer. Thus, the goal of this project is to identity key regulators and mechanisms that control the maintenance of healthy skin by regulating stem cell growth and differentiation. Once we have identified important factors regulating stem cell fate, we further investigate whether their mis-regulation contribute to cancer. These approaches are being developed and exploited to uncover novel mechanisms and pathways that are involved in cancer development and could well lead to the discovery of novel anti-cancer drug targets.