Impact of peripheral inflammation on cerebrovascular disease

大脑的血液供应提供必要的氧气和营养物质，以支持大脑功能。在中风期间，大脑的血液供应可能会减少或堵塞。这会导致大脑中的神经细胞死亡，这对患者来说可能是致命的，也可能导致它们严重残疾。尽管有一些治疗中风的方法可用，但这些方法并不适用于所有患者，也不总是广泛有效。因此，我们需要更多地了解中风发生的原因以及是什么导致脑细胞死亡，以便开发新的治疗方法。炎症是身体对抗感染的反应，但它也可能导致各种疾病，如关节炎和哮喘。发生在大脑之外的炎症，例如发生在血管中的炎症，可能会导致中风等疾病的发展，并使患者病情恶化。因此，在这项提议中，我们的目的是了解大脑外部的炎症和感染如何影响大脑内的事件。为了做到这一点，我们将研究与许多人类大致相同的血管疾病的动物，看看这是否会导致中风，如果是的话，是如何引起的。这些研究应该有助于我们找到更好的人类中风动物模型，在其中测试新的治疗方法。我们还致力于发现血液或大脑中可以预测中风等脑部疾病发生的物质，以便患者能够及早得到治疗。

The blood supply to the brain provides essential oxygen and nutrients to support brain function. During stroke the blood supply to the brain may be reduced or blocked. This causes nerve cells in the brain to die, which can be fatal for the patient or leave them severely disabled. Although some treatments are available for stroke, these are not suitable for all patients and not always widely effective. We need therefore to understand more about why stroke occurs and what causes the brain cells to die so that new treatments can be developed.Inflammation is the response of the body to fight infection, but it can also lead to a variety of diseases, such as arthritis and asthma. The inflammation that occurs outside the brain, for example in a blood vessel, can contribute to the development of conditions such as stroke and make the patient much worse. Therefore in this proposal our aim is to understand how inflammation and infection outside the brain affect events within the brain. To do this we will study animals that develop disease of their blood vessels in much the same way that many humans do, to see if this causes strokes and, if so, how. The studies should help us to identify better animal models of human stroke in which to test new treatments. We also aim to discover substances within the blood or brain that can predict the occurrence of brain diseases such as stroke, so that patients can be treated early.