DIFFERENTIATION OF LEISHMANIA PROMASTIGOTES

超环前鞭毛体对易感脊椎动物有很强的致病力 主持人。这种毒力似乎与偏环病毒的能力有关。 通过替代补体途径抵抗杀伤的形式，以及它们的 抵抗正常居民杀微生物活性的能力 巨噬细胞。一种识别细胞的单抗已经问世。 表面和分泌的分子，这是超环前鞭毛体所独有的。 它似乎是感染性疾病患者主动分泌的唯一分子。 阶段性生物。因此，它很可能扮演着一个生物学上的关键角色 在促进成功的寄生方面的作用。它的化学成分和作用方式 正在被追捕。 每年大约有2个月的时间用来研究 印度北部的内脏利什曼病。患有活动性疾病的患者有 尤其是在T细胞水平上对利什曼病毒抗原没有反应。 这种无反应性不能通过耗尽T8“抑制者”来逆转。 细胞或通过与IL-2重组。我们最近检测到一种 可能有大量接触过病毒的无症状个体 基于体内和体内对寄生虫抗原的反应性的流行区 体外培养。“免疫”T细胞识别的抗原的性质是 正在研究中。

Metacyclic promastigotes are highly virulent to a susceptible vertebrate host. This virulence appears to be related to the ability of metacyclic forms to resist killing by the alternative complement pathway, and to their ability to resist the microbicidal activities of normal resident macrophages. A monoclonal antibody has been raised which recognizes a cell surface and secreted molecule which is unique to metacyclic promastigotes. It appears to be the exclusive molecule actively secreted by infective stage organisms. It is, therefore, likely to play a biologically critical role in promoting successful parasitism. Its chemistry and mode of action are being pursued. Approximately 2 months of each year are spent studying the immunology of visceral leishmaniasis in north India. Patients with active disease are specifically unresponsive at the T cell level to leishmanial antigens. This unresponsiveness cannot be reversed by depletion of T8 "suppressor" cells or by reconstitution with IL-2. We have recently detected a potentially large population of exposed, asymptomatic individuals from endemic areas based on their reactivity to parasite antigens in vivo and in vitro. The nature of the antigens recognized by the "immune" T cells is under study.