ASSESSMENT OF THE SIZE OF THE LEAK INDUCED IN RETINAL VESSELS USING PITC-DEXTRANS

用IRBP和SERIAL免疫两只猴子诱发葡萄膜炎 使用不同大小的葡聚糖链连接的荧光素血管造影 荧光素。这些研究的目的是提供有关视网膜的数据 血管和毒理学数据，使这些制剂能够用于人类。 我们已经证明，分子量越大的右旋糖苷越少 在发炎的视网膜中比荧光素钠更易感染。

Uveitis was induced in two monkeys by immunization with IRBP and serial fluorescein angiograms preformed using different sized dextrans linked to fluorescein. The aim of these studies is to provide data on the retinal vessels and toxicology data to enable these agents to be used in humans. We have demonstrated that the larger molecular weight dextrans are less premeable than sodium fluorescein in the inflamed retina.