Oxidized phospholipid ionic transduction mechanism of human vascular cells

至少有一半的欧洲人死于心血管疾病，往往是过早死亡和长期残疾。有令人信服的证据表明，这种疾病和一些相关疾病是由不必要的炎症、过度氧化应激、不活动和高脂肪负荷引起或加速的。过去十年的开创性研究已经确定了疾病条件下的特殊类型的脂肪（脂质），统称为氧化磷脂。有充分的证据表明，氧化磷脂在心血管疾病中起着关键作用，但对细胞如何感知或响应脂质却知之甚少；或者防御他们。在我们对心血管疾病患者血管细胞的新研究中，我们发现了一种惊人的脂质初始接受机制，因此提出了对该机制如何工作以及编码该机制的基因的研究。通过这项工作，我们将为人类生物学的一个重要而鲜为人知的领域提供新的见解，并为与人类主要疾病高度相关的有价值的治疗干预奠定基础。

At least half of the European population dies from cardiovascular disease, often prematurely and following prolonged periods of disability. There is compelling evidence that this type of disease and several related diseases are caused, or accelerated, by unwanted inflammation, excessive oxidative stress, inactivity, and high fat load. Seminal studies over the past decade have identified special types of fat (lipid) in the disease conditions that are collectively referred to as oxidized phospholipids. There is excellent evidence that oxidized phospholipids play pivotal roles in cardiovascular disease but there is little fundamental understanding of how cells sense or respond to the lipids; or defend against them. In our new studies of vascular cells from patients with cardiovascular disease we have identified a striking initial reception mechanism for the lipids and so propose investigation of how the mechanism works as well as identification of genes that encode the mechanism. Through this work we will provide new insight into an important and poorly understood area of human biology and lay the foundations for valuable therapeutic interventions with high relevance to major human diseases.