The importance of Spleen tyrosine kinase (Syk) as a potential therapeutic target in glomerulonephritis

抗体介导的疾病是那些由身体引起的？我们的免疫系统针对我们自己的器官。当这种情况发生在肾脏时，它会引起炎症，称为肾小球肾炎。这是肾衰竭的常见原因。目前对这种情况的治疗并不总是有效的，可能有严重的副作用。我们已经证明，一种名为R788的药物在治疗免疫介导的肾小球肾炎动物方面非常有效。R788还可有效治疗人类其他形式的免疫介导疾病，如类风湿性关节炎。我想研究这种药物是否是一种有用和安全的治疗人类肾小球肾炎的方法。我将通过比较R788对取自人类和肾小球肾炎动物的白色血细胞和肾细胞的影响来实现这一点。我的目标是确定药物是否？的靶分子是否存在于人体细胞中，如果存在，它是否在降低炎症水平和负责自身免疫的抗体方面具有活性。这些信息可能为将来R788在肾小球肾炎患者中的临床试验提供基础。我将沿着来自伦敦帝国理工学院肾脏和移植研究所的其他医生进行这项研究。

Antibody-mediated diseases are those caused by the body?s immune system targeting our own organs. When this occurs in the kidneys it causes inflammation, called glomerulonephritis. This is a common cause of kidney failure. Current treatments for this condition are not always effective and may have severe side-effects. Better and safer treatment is needed.We have shown that a drug called R788 is extremely effective in treating animals with immune-mediated glomerulonephritis. R788 is also effective in treating humans with other forms of immune-mediated disease, such as rheumatoid arthritis. I would like to investigate whether this drug would be a useful and safe treatment for glomerulonephritis in humans.I will achieve this by comparing the effects of R788 on white blood cells and kidney cells taken from humans and animals with glomerulonephritis. I aim to establish if the drug?s target molecule is present in human cells, and if so, whether it is active in reducing levels of inflammation and the antibodies responsible for autoimmunity. This information may provide the basis for a future clinical trial of R788 in humans with glomerulonephritis.I will undertake this research along with other doctors from the Imperial College Kidney and Transplant Institute in London.