New roles for the spleen tyrosine kinase in antibody-independent renal injury.
New roles for the spleen tyrosine kinase in antibody-independent renal injury.
批准号:
nhmrc : 1002079
负责人:
A/Pr David Nikolic-Paterson
金额:
$38.33万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2013-12-31
中文摘要
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英文摘要
This study investigates the novel hypothesis that a particular cell activation pathway (called Syk) is important not only in antibody-based kidney disease, but that it also plays a previously unrecognised role in other forms of antibody-independent kidney disease. Drugs that inhibit the Syk pathway are in clinical development for treatment of diseases such as arthritis. Hence, a positive outcome of this project could lead to the use of Syk inhibitors in many different types of kidney disease.
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会议论文
TGF-beta/Smad signalling in macrophage-mediated renal fibrosis.
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批准号:nhmrc : 1122073
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项目类别:Project Grants
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Defining the central role of podocyte depletion in the development, progression and management of glomerular disease
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财政年份:2017
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依托单位:
Defining the central role of podocyte depletion in the development, progression and management of glomerular disease
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批准号:nhmrc : 1121793
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项目类别:Project Grants
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资助金额:$47.17万
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财政年份:2017
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
TGF-beta/Smad signalling in macrophage-mediated renal fibrosis.
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批准号:nhmrc : GNT1122073
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项目类别:Project Grants
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资助金额:$68.37万
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财政年份:2017
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依托单位:
Mineralocortioid Receptor-Mediated Injury in Progressive Kidney Disease
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批准号:nhmrc : GNT1102882
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项目类别:Project Grants
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资助金额:$70.7万
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财政年份:2016
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Mineralocortioid Receptor-Mediated Injury in Progressive Kidney Disease
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批准号:nhmrc : 1102882
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项目类别:Project Grants
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资助金额:$48.47万
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财政年份:2016
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Modulating Inflammatory and Fibrogenic Pathways in Kidney Disease using a novel antagonist of Protease-Activated-Receptor-2
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批准号:nhmrc : 1083131
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项目类别:Project Grants
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资助金额:$39.89万
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财政年份:2015
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Modulating Inflammatory and Fibrogenic Pathways in Kidney Disease using a novel antagonist of Protease-Activated-Receptor-2
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批准号:nhmrc : GNT1083131
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项目类别:Project Grants
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资助金额:$38.75万
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财政年份:2015
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Spleen tyrosine kinase (Syk) as a therapeutic target in antibody-dependent transplant rejection.
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批准号:nhmrc : 1057565
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项目类别:Project Grants
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资助金额:$41.74万
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财政年份:2014
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
New strategies for the treatment of kidney disease.
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批准号:nhmrc : GNT1058175
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项目类别:Research Fellowships
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资助金额:$66.45万
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财政年份:2014
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Mechanistic and translational studies targeting kidney inflammation and fibrosis.
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批准号:nhmrc : 1058175
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项目类别:Research Fellowships
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资助金额:$46.49万
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财政年份:2014
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Smad3 acetylation modulates organ fibrosis
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批准号:nhmrc : 1057581
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项目类别:Project Grants
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资助金额:$45.55万
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财政年份:2014
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Apoptosis signal-regulating kinase 1 (ASK1) is a major pathway of stress-induced renal injury in different types of progressive kidney disease.
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批准号:nhmrc : 1044289
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项目类别:Project Grants
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资助金额:$45.27万
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财政年份:2013
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Distinct pathogenic roles for JNK signalling in glomerular and interstitial injury in kidney disease.
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批准号:nhmrc : 1006348
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项目类别:NHMRC Project Grants
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资助金额:$37.07万
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财政年份:2011
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Resolvin E1 is a novel anti-inflammatory and anti-fibrotic lipid mediator for the treatment of chronic kidney disease.
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批准号:nhmrc : 606400
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项目类别:NHMRC Project Grants
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资助金额:$34.62万
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财政年份:2010
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Selective targeting of acute renal injury by inhibition of the receptor tyrosine kinase, c-fms.
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批准号:nhmrc : 606685
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项目类别:NHMRC Project Grants
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资助金额:$29.54万
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财政年份:2010
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
TAK1 - a novel regulator of renal inflammation and fibrosis.
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批准号:nhmrc : 494822
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项目类别:NHMRC Project Grants
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资助金额:$35.85万
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财政年份:2008
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Therapeutic targetting of MIF in type 2 diabetes
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批准号:nhmrc : 494823
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项目类别:NHMRC Project Grants
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资助金额:$34.65万
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财政年份:2008
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负责人:A/Pr David Nikolic-Paterson
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依托单位:
Lefty - a novel anti-fibrotic molecule for the treatment of kidney disease
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批准号:nhmrc : 388902
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项目类别:NHMRC Project Grants
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资助金额:$28.4万
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财政年份:2007
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负责人:A/Pr David Nikolic-Paterson
-
依托单位:
Role of JNK and p38 MAPK signalling in diabetic nephropathy
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批准号:nhmrc : 338517
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项目类别:NHMRC Project Grants
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资助金额:$30.31万
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财政年份:2005
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负责人:A/Pr David Nikolic-Paterson
-
依托单位:
海外基金