New roles for the spleen tyrosine kinase in antibody-independent renal injury.

脾酪氨酸激酶在抗体非依赖性肾损伤中的新作用。

• 批准号: nhmrc : 1002079
• 负责人: A/Pr David Nikolic-Paterson
• 金额: $ 38.33万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/new-roles-spleen-renal-injury/108770
• 关键词: New; roles; spleen; tyrosine; kinase

This study investigates the novel hypothesis that a particular cell activation pathway (called Syk) is important not only in antibody-based kidney disease, but that it also plays a previously unrecognised role in other forms of antibody-independent kidney disease. Drugs that inhibit the Syk pathway are in clinical development for treatment of diseases such as arthritis. Hence, a positive outcome of this project could lead to the use of Syk inhibitors in many different types of kidney disease.

这项研究调查了一个新的假设，即一种特定的细胞激活途径（称为 Syk）不仅在基于抗体的肾脏疾病中很重要，而且在其他形式的抗体非依赖性肾脏疾病中也发挥着以前未被认识到的作用。抑制 Syk 通路的药物正在临床开发中，用于治疗关节炎等疾病。因此，该项目的积极成果可能会导致 Syk 抑制剂在许多不同类型的肾脏疾病中的使用。