Development of an efficient, robust MS-based platform for early detection of acute kidney injury

急性肾损伤(AKI)是住院患者的严重并发症，是一种威胁生命的并发症，至今仍有很高的死亡率。此外，AKI与强化和长期治疗的高成本有关。到目前为止，还不可能及早发现AKI。然而，早期发现对于启动适当的治疗至关重要，从而防止疾病的发展，或至少减轻严重程度。这样的做法将降低死亡率，并降低成本。该提案旨在开发一种技术平台，能够根据尿液中的特定蛋白质和多肽，即所谓的生物标记物，及早检测AKI。这些生物标志物已经被识别出来了。为了有效的临床应用，必须开发一种能够进行准确和快速分析的平台，这一开发就是该项目的范围。在该项目成功完成后，将有一种强大的技术可用于及早发现AKI，从而启动适当的早期治疗措施。我们预计，由于这个项目的结果，AKI的死亡率可以显著降低，成本可以降低。

Acute Kidney Injury (AKI) as a severe complication in hospitalized patients, a life-threatening complication that still has a high mortality. In addition, AKI is associated with high costs for intensive and prolongued treatment. To date, no early detection of AKI is possible. However, early detection is essential to initiate appropriate treatment, thereby preventing development of disease, or at least reducing the severity. Such an appproach would reduce mortality, and also costs. The proposal aims at developing a technology platform that enables early detection of AKI, based on specific proteins an peptides in urine, so-called biomarkers. These biomarkers have already been identified. For their efficient clinical application a plattform that allows accurate and fast analysis has to be developed, this development is the scope of the project. Upon successful completion of the project, a robust technology will be available that enables early detection of AKI, hence initiation of appropriate early therapeutic measures. We anticipate that as a result of this project, mortality due to AKI can be significantly decreased, and costs can be reduced.