The 1958 Birth Cohort Biomedical Resource - facilitating access to data and samples and enhancing future utility

1958年出生队列（1958 BC）招募了1958年3月一周内在英国出生的所有儿童的98%（17，416）。此后，参与者被纵向跟踪，并参加了多达8次社会科学主导的调查（1965-2008年）以及一系列其他特别倡议和媒体活动。但是，尽管公元前1958年取得了明显的科学成就，新千年的战略思想表明需要进行额外的生物医学重点调查。生物医学调查发生在2002-2003年（参与者年龄44-45岁）根据MRC？是什么？公众的健康？倡议总共联系了12，037名受试者，采访了9，377人。其目的是通过问卷调查，物理测量和生物标本收集获得关键的生物医学信息，并利用这些信息来研究发展，生活方式和环境因素如何在整个生命周期中影响健康状况不佳，以及中年早期的生理和心理功能。与此同时，Wellcome Trust资助了从调查中的生物样本中创建永生细胞系，这些细胞系现在为7，500多名研究参与者提供了无限的DNA来源。生物医学资源现在整合了生物医学调查的所有数据和样本，随后为英国生物科学提供了一个很好的资源。自2002年以来，世界各地（主要是英国）的研究小组获得了超过658个数据和样本奖项，到目前为止，已有350多个同行评审的出版物基于这些奖项。也许最令人印象深刻的是，1958年的生物医学资源在威康信托病例对照联盟（WTCCC）中提供了3,000个对照，调查了导致8种重要慢性疾病的基因，包括糖尿病，冠状动脉疾病和抑郁症。WTCCC被指定为国际？年度研究负责人？在2008年1月的《科学美国人》杂志上。但是，生物医学资源及其获取都需要谨慎的管理和深思熟虑的战略发展。这项基础设施拨款来自莱斯特大学和布里斯托大学，反映了MRC、WT和ESRC的战略思维。它将确保在2014年之前数据和样本的可持续获取以及资源的战略发展。该提案包含三个相辅相成的目标：（1）保障基本基础设施;（2）从行政和战略管理角度加强基础设施;（3）从科学角度加强基础设施。这些目标将确保1958 BC和英国生物科学能够最好地面对未来的科学挑战。

The 1958 Birth Cohort (1958BC) recruited 98% (17,416) of all children born in Great Britain during one week in March 1958. Participants have since been followed longitudinally and have taken part in up to eight further social-science-led surveys (1965-2008) as well as a range of other special initiatives and media events. But, despite the undoubted scientific success of 1958BC, strategic thinking in the new Millennium suggested the need for an additional bio-medically focussed survey. The Biomedical Survey took place in 2002-2003 (participants aged 44-45) under the MRC?s ?Health of the Public? initiative. In total, 12,037 subjects were contacted and 9,377 were interviewed. The aim was to obtain critical biomedical information via questionnaires, physical measures and biospecimen collection and to use this to examine how developmental, lifestyle, and environmental factors act throughout the lifespan to influence ill health, and physiological and psychological function in early middle age. At the same time, the Wellcome Trust funded creation of immortal cell lines from the biosamples in the Survey and these now provide an unlimited source of DNA in more than 7,500 study participants. The Biomedical Resource that now integrates all of the data and samples from the biomedical survey has subsequently provided a wonderful enabling resource for UK Bioscience. More than 658 awards of data and samples have been made to research groups across the world (mainly in UK) since 2002 and, so far, more than 350 peer reviewed publications have been based on these awards. Perhaps most impressively, the 1958BC Biomedical Resource provided 3,000 controls in Wellcome Trust Case Control Consortium (WTCCC) that investigated the genes causing 8 important chronic diseases including diabetes, coronary artery disease and depression. WTCCC was designated international ?Research Leader of the Year? in by Scientific American Magazine in January 2008. But the Biomedical Resource and access to it both require careful management and thoughtful strategic development. This infrastructural grant, coming jointly from the Universities of Leicester and Bristol, reflects strategic thinking at MRC, WT and ESRC. It will secure sustainability of data and sample access and strategic development of the Resource until 2014. The proposal subsumes three complementary objectives: (1) secure the basic infrastructure; (2) enhance the infrastructure from an administrative and strategic management perspective; (3) enhance the infrastructure from a scientific perspective. These objectives will ensure that both the 1958BC, and UK Bioscience, are best placed to face the scientific challenges of the future.