The 1958 Birth Cohort Biomedical Resource - facilitating access to data and samples and enhancing future utility

1958年出生队列（1958 bc）在1958年3月的一周内招募了98%（17416）在英国出生的儿童。从那以后，研究人员对参与者进行了纵向跟踪，并参加了多达8次以社会科学为主导的调查（1965年至2008年），以及一系列其他特别倡议和媒体活动。但是，尽管在公元前1958年取得了毫无疑问的科学成功，但新千年的战略思考表明，需要进行额外的以生物医学为重点的调查。生物医学调查于2002-2003年进行（参与者年龄44-45岁）。年代?公众健康？倡议。总共联系了12037名受试者，采访了9377名受试者。目的是通过问卷调查、物理测量和生物标本收集获得关键的生物医学信息，并利用这些信息来研究发育、生活方式和环境因素在整个生命周期中如何影响中年早期的健康状况和生理和心理功能。与此同时，Wellcome Trust资助了从调查中的生物样本中创造出永生细胞系，这些细胞系现在为7500多名研究参与者提供了无限的DNA来源。生物医学资源现在整合了来自生物医学调查的所有数据和样本，随后为英国生物科学提供了一个美妙的使能资源。自2002年以来，世界各地（主要在英国）的研究小组获得了超过658个数据和样本奖，到目前为止，已有350多份同行评议出版物基于这些奖项。也许最令人印象深刻的是，1958BC生物医学资源在威康信托病例控制联盟（WTCCC）中提供了3000个对照，调查了导致8种重要慢性疾病的基因，包括糖尿病、冠状动脉疾病和抑郁症。WTCCC被指定为国际性的？年度研究领袖？发表在2008年1月的《科学美国人》杂志上。但是生物医学资源及其获取都需要谨慎的管理和深思熟虑的战略发展。这项基础设施拨款由莱斯特大学和布里斯托尔大学联合提供，反映了MRC、WT和ESRC的战略思维。它将确保数据和样本获取的可持续性以及资源的战略发展，直到2014年。该建议包含三个互补的目标：(1)确保基础设施的安全；(2)从行政和战略管理的角度加强基础设施建设；(3)从科学角度加强基础设施建设。这些目标将确保1958BC和英国生物科学能够最好地面对未来的科学挑战。

The 1958 Birth Cohort (1958BC) recruited 98% (17,416) of all children born in Great Britain during one week in March 1958. Participants have since been followed longitudinally and have taken part in up to eight further social-science-led surveys (1965-2008) as well as a range of other special initiatives and media events. But, despite the undoubted scientific success of 1958BC, strategic thinking in the new Millennium suggested the need for an additional bio-medically focussed survey. The Biomedical Survey took place in 2002-2003 (participants aged 44-45) under the MRC?s ?Health of the Public? initiative. In total, 12,037 subjects were contacted and 9,377 were interviewed. The aim was to obtain critical biomedical information via questionnaires, physical measures and biospecimen collection and to use this to examine how developmental, lifestyle, and environmental factors act throughout the lifespan to influence ill health, and physiological and psychological function in early middle age. At the same time, the Wellcome Trust funded creation of immortal cell lines from the biosamples in the Survey and these now provide an unlimited source of DNA in more than 7,500 study participants. The Biomedical Resource that now integrates all of the data and samples from the biomedical survey has subsequently provided a wonderful enabling resource for UK Bioscience. More than 658 awards of data and samples have been made to research groups across the world (mainly in UK) since 2002 and, so far, more than 350 peer reviewed publications have been based on these awards. Perhaps most impressively, the 1958BC Biomedical Resource provided 3,000 controls in Wellcome Trust Case Control Consortium (WTCCC) that investigated the genes causing 8 important chronic diseases including diabetes, coronary artery disease and depression. WTCCC was designated international ?Research Leader of the Year? in by Scientific American Magazine in January 2008. But the Biomedical Resource and access to it both require careful management and thoughtful strategic development. This infrastructural grant, coming jointly from the Universities of Leicester and Bristol, reflects strategic thinking at MRC, WT and ESRC. It will secure sustainability of data and sample access and strategic development of the Resource until 2014. The proposal subsumes three complementary objectives: (1) secure the basic infrastructure; (2) enhance the infrastructure from an administrative and strategic management perspective; (3) enhance the infrastructure from a scientific perspective. These objectives will ensure that both the 1958BC, and UK Bioscience, are best placed to face the scientific challenges of the future.