Designing novel apolipoprotein A1 mimetic peptides as drug treatment for atherosclerosis

心血管疾病是动脉粥样硬化斑块的形成所造成的不平衡之间的数量的胆固醇交付和从动脉中删除。载脂蛋白A-1（ApoA-1）是高密度脂蛋白（HDL）的主要蛋白质，具有清除细胞外胆固醇的作用。在这个项目中，我们的目的是设计和测试新的药物（ApoA 1-模拟肽），这将引起相同的抗动脉粥样硬化性质的apoA-1，作为一种治疗剂，用于预防动脉粥样硬化。

Cardiovascular disease is the formation of atherosclerotic plaques caused by the imbalance between the amount of cholesterol delivered and removed from the arteries. Apolipoprotein A-1 (ApoA-1) is the main protein of high density lipoprotein (HDL) and removes cholesterol out of cell. In this project we are aimed at designing and testing new drugs (ApoA1-mimetic peptides) which will elicit the same anti-atherogenic properties as apoA-1, as a therapeutic agent for prevention of atherosclerosis.