STUDIES OF CHILDHOOD SOLID TUMORS

这项计划的最终目标是治愈患有 癌症。该计划是治疗和研究的协调努力， 包括治疗试验，肿瘤细胞生物学研究，以及 治疗对正常组织的影响。该程序由一个核心组成 部分和四个项目。核心部分提供资源 人员、患者数据库、生物统计学和两个资源实验室 功能--一个组织培养和细胞遗传学实验室和一只动物 异种移植发育实验室。这些项目是：(1)神经母细胞瘤 治疗和细胞生物学；(2)横纹肌肉瘤：实验模型 药理学研究；(3)尤文氏肉瘤的治疗和细胞动力学 以及生物学行为的特点；(4)新的一期和二期试验 治疗难治性肿瘤的药物。所有的项目都有相同的终极目标 目的通过多种学科和方法开展临床研究。这个 组织结构为实现统一协调提供了手段 努力。

The ultimate objective of this program is the cure of children with cancer. The program is a coordinated effort of therapy and study which includes therapeutic trials, studies of tumor cell biology, and studies of the effects of therapy on normal tissues. The program consists of a core section and four projects. The core section provides for resource personnel, patient data base, biostatistics, and two resource laboratory functions - a tissue culture and cytogenetics laboratory and an animal xenograft developmental laboratory. The projects are: (1) neuroblastoma therapy and cell biology; (2) rhabdomyosarcoma: a laboratory model for pharmacological studies; (3) Ewing's sarcoma therapy and cell kinetics as well as features of biological behavior; (4) phase I and II trials of new agents for refractory tumors. All projects have the same ultimate objective through a variety of disciplines and approaches. The organizational structure provides the means for unified and coordinated effort.