Developmental Clinical Studies - development of vitamin D therapy to prevent acute lung injury.

这项研究的目的是开发维生素D作为预防急性肺损伤的治疗方法。急性肺损伤ALI是危重病患者发生肺功能衰竭的主要原因。大多数受影响的患者处于工作年龄，幸存者的健康相关生活质量显著下降，46%的患者无法在12个月内重返工作岗位。目前，除了有创的保护性呼吸机外，没有任何治疗方法被确凿地证明可以降低存活者的死亡率或改善其功能预后。这代表着一个重大的未得到满足的卫生需求。通过开展这项研究，我们将确定简单而廉价的维生素D替代是否会影响急性肺损伤的发展和严重程度。

The aim of this research is to develop vitamin D as a therapy to prevent acute lung injury. Acute lung injury ALI is a major cause of lung failure in critically ill patients. Most patients affected are of working age and survivors experience a significant reduction in health-related quality of life, with 46% unable to return to work within 12 months. Currently, apart from invasive protective ventilation, no therapy has been conclusively proven to reduce mortality or improve functional outcome in survivors. This represents a major unmet health need. By undertaking this research we will establish if simple and cheap replacement of vitamin D influences the development and severity of acute lung injury.