Characterisation of the bacterial proteins YjeE, YeaZ and YgjD and evaluation as a potential novel antimicrobial target

细菌有许多在任何其他形式的生命中都没有发现的蛋白质，其中一些已经被证明是细菌生存所必需的。该项目旨在探索一组三种基本细菌蛋白质相互作用的方式，并试图了解它们在细菌中扮演的关键角色。有了这些知识，我们就会发现扰乱这些过程的小分子，这些小分子可能最终会被开发成治疗细菌感染的新药。细菌的抗药性正在增加，随之而来的是难以治疗的感染的数量也在增加。我们将研究的蛋白质网络不会受到我们目前使用的抗生素的攻击，因此可能成为新抗生素的潜在目标，当细菌对目前的抗生素产生耐药性时，这些抗生素可能是有效的。

Bacteria have a number of proteins that are not found in any other form of life, and some of these have been shown to be essential for bacteria to survive. This project aims to explore the way a set of three essential bacterial proteins interact with each other and to try to understand the critical roles that they play within the bacterium. Armed with this knowledge we would then like to discover small molecules that disrupt these processes, which might be ultimately developed as new drugs to treat bacterial infections.Antibiotic resistance in bacteria is increasing, and with it the number of hard-to-treat infections also increases. The network of proteins we will investigate is not attacked by the antibiotic agents we currently use, and so may be a potential target for new antibiotic agents that may be effective when the bacteria are resistant to out current antibiotics.