EXPERIMENTAL AND CLINICAL PHARMACOGENETICS

药物代谢和毒性的药物遗传学研究程序 建议对药物和其他环境化学品进行管制。调查 将在人类家庭中进行，在基因定义的实验中进行 动物模型，以及人类和动物组织的亚细胞系统。这 是一个跨学科的项目，结合了药理学的研究人员 以及扩展到生物化学的人类和老鼠遗传学， 毒理学和分子生物学。 具体地说，该计划将进行1)研究，以确定 快慢同工酶的结构和功能性质差异 乙酰化N-乙酰转移酶；2)实验和临床研究 人血清酯酶检测的意义及相关性 有机磷毒性与药物代谢；3)分子生物学 (基因克隆)研究，以确定遗传差异是否在 常见的人血清胆碱酯酶及其同工酶变体是 是由DNA多态引起的。

A program of pharmacogenetic investigation in drug metabolism, and toxicity of drugs and other environmental chemicals is proposed. The investigations will be performed in human families, in genetically defined experimental animal models, and subcellular systems of human and animal tissues. This is an interdisciplinary program combining investigators from pharmacology and human and mouse genetics with extensions into biological chemistry, toxicology and molecular biology. Specifically, the program will undertake 1) studies to determine the structural and functional nature of isozymic differences of rapid and slow acetylator N-acetyltransferases; 2) experimental and clinical studies to determine the significance and relationship of human serum esterases to organophosphate toxicity and drug metabolism; and 3) molecular biology (gene cloning) studies to determine whether the hereditary difference in the usual human serum cholinesterase and its isozymic variants are accounted for by DNA polymorphisms.