NEUROPHYSIOLOGY/PSYCHOLOGY IN MENTAL RETARDATION

该提案的目的是进行基础和临床研究 神经生理学、神经解剖学和神经心理学的各个方面， 提高对智力迟钝及相关问题的认识， 人类发展 这一目标将通过利用人才来实现 研究人员以合作和协作的方式。 该小组的成员将承担下列任务： 1.行为、电生理和形态学的应用 研究动物正常发育和改变的技术 由于新生儿脑损伤或 环境操控 这些研究旨在阐明 神经基础受损的表现，并提供动物模型， 精神发育迟滞的种类。 2.研究正常和异常方面的机制， 学习，包括塑料的细胞基础的调查 行为，并在可能的情况下，细胞膜生理学与 超微结构分析 在一个新的项目中， 将讨论培养的CNS神经元中的突触。 3.在人类受试者和动物中进行的平行研究旨在 探讨正常人和异常人的听觉信息加工 大脑的长期目标是了解异常的性质 弱智人的听觉处理。 4.为吸引和培训青年科学家提供环境 在相关的研究领域。

The aim of this proposal is to pursue research in basic and clinical aspects of neurophysiology, neuroanatomy, and neuropsychology relevant to an increased understanding of mental retardation and related aspects of human development. This aim will be implemented by utilizing the talents of researchers in a cooperative and collaborative manner. Members of this group will undertake the following tasks: 1. The application of behavioral, electrophysiological and morphological techniques in studies of normal development in animals and of alterations in normal development as a consequence of neonatal brain insult or environmental manipulation. These studies are designed to elucidate the neural bases of impaired performance and to provide animal models of species of mental retardation. 2. A study of the mechanisms underlying normal and abnormal aspects of learning, including investigations of the cellular bases of plastic behavior and, where possible, correlation of cell membrane physiology with ultrastructural analysis. In a new project, studies of the development of synapses in cultured CNS neurons will be addressed. 3. Parallel studies in human subjects and in animals designed to investigate auditory information processing in the normal and abnormal brain with the long-range goal of understanding the nature of abnormal auditory processing in the retarded human. 4. The provision of a milieu for attracting and training young scientists in related research areas.