Motion and Sleep: Neuropsychology and Biomarkers

在“光流”提供主导信息的3D视觉和引力世界中，机动性或“自我运动”是适应和生存的基础。来自前庭和动觉系统的正常信息必须整合在一起，为自我运动提供一个共同的神经框架。相互冲突的感觉-运动条件可能会重新安排视觉、前庭和动觉线索之间的正常关系。在移动的环境中，易受影响的受试者可能会出现晕动病或虚幻的自我运动，并伴有认知功能障碍。松果体褪黑素调节睡眠-觉醒周期、嗜睡、情绪和认知表现。太空病的前庭刺激变化可能会改变睡眠，这与sopite综合征有关，有时是唯一的晕动病表现。垂体ACTH和肾上腺皮质醇调节唤醒、压力和晕动病易感性的水平。认知能力和神经激素的变化发生在自我运动和晕动病中。该建议的目的是：将年轻的男性和女性成年人暴露在旋转的光动力眼球震颤鼓中的光学显示器中，以产生圆形vection （CV）和sopite综合征（SSS）的症状，并确定小剂量[0或3 mg]口服（舌下）褪黑激素是否会影响内源性唾液褪黑激素和皮质醇的水平，或增加CV和SSS的发病率、潜伏期和严重程度。建议的商业应用：如果sopite综合征和褪黑激素相关，那么可能会开发出对嗜睡或睡眠有兴趣的预测或控制产品。这项研究显然将产生具有高度竞争力的风险风险评估技术，预计将率先推向市场。通过这个项目的最终目标是开发一个可行的产品或产品线，并成功地将其推向市场。RSK在之前的创新产品的营销和分销方面取得了一些成功，但为了确保之前和未来项目的大幅增长，我们正在大力发展我们的营销策略。

Mobility or "self-motion" is fundamental for adaptation and survival in 3D visual and gravitational worlds where "optic flow" provides dominant information. Normal information from vestibular and kinesthetic systems must be integrated to provide a common neural framework for self-motion. Conflicting sensory-motor conditions may rearrange normal relations among visual, vestibular, and kinesthetic cues. In moving environments, susceptible subjects may experience motion sickness or illusory self-motion, with cognitive performance disturbances. Pineal melatonin modulates sleep-wake cycles, drowsiness, mood, and cognitive performance. Sleep may be altered by vestibular stimulation changes in space sickness through relationships with the sopite syndrome, sometimes the sole motion sickness manifestation. Pituitary ACTH and adrenal cortisol regulate level of arousal, stress, and motion sickness susceptibility. Changes in cognitive performance and neurohormones occur in self-motion and in motion sickness. The aims of this proposal are to: expose young male and female adults to an optic display in a rotating optokinetic nystagmus drum to produce circular vection (CV) and symptoms of the sopite syndrome (SSS), and to determine whether small doses [0 or 3 mg] of oral (sublingual) melatonin can affect levels of endogenous salivary melatonin and cortisol, or increase the incidence, latency, and severity of CV and SSS. PROPOSED COMMERCIAL APPLICATION: If sopite syndrome and melatonin can be related then it is possible that products will be developed where prediction or control of drowsiness or sleep are of interest. This research will clearly result in highly competitive technologies for RSK Assessments which are expected to be first to market. The ultimate objective through this project is to develop a viable product or product line and successfully bring it to market. RSK has experienced some success with the marketing and distribution of previous innovations, but to ensure substantial growth on previous and future projects, we are significantly developing our marketing strategies.