PSYCHOPHYSIOLOGICAL RESPONSIVITY AND BEHAVIOR IN SCHIZOPHRENIA

本项目的总体目的是调查 自主神经系统(ANS)的活动、注意力和信息 病理、病因学及病原学中的加工及其相互关系 精神疾病的预后。第二个目的是确定 与ANS活动有关的生物和心理过程 请注意。ANS活性通过外周测量进行评估，例如皮肤 电导、心率和皮肤温度。受试者在以下条件下进行测试 休息条件，音调的呈现，以及任务的表现，如 反应时间和两次闪光辨别。 生物机制的研究是通过将这些变量与 酶活性、神经肽和生物胺及其水平 代谢物。 目前正在对未经药物治疗的诊断为 精神分裂症，情感障碍，强迫症， 焦虑-惊恐障碍和自闭症，以测试诊断的特异性 ANS活动的模式。状态更改的影响在以下情况下进行了研究 多重人格，以及CT显示的脑功能障碍 还有正电子发射计算机断层扫描。在一些研究中，血液样本是在ANS期间采集的 在给出紧张程序的过程中进行录音。在一个方面， 评估成功和未能逃脱令人厌恶的噪声的影响， 在另一项研究中，一剂育亨宾的效果正在研究中。 对各种治疗方法的临床试验进行了研究。这些药物包括吡莫齐特， 普萘洛尔、维拉帕米和血液透析治疗精神分裂症、氯吉林和维拉帕米 强迫症患者使用氯丙咪嗪，惊恐焦虑症患者使用阿普唑仑和丙咪嗪 病人。 心理相关研究通过临床背景数据、临床 评级和问卷，以及程序上的差异。对.的使用 验证性因子分析在数据约简中的应用及改进 正在探索ANS活动的量化。

The general purpose of this project is to investigate the roles of autonomic nervous system (ANS) activity, attention, and information processing and their interrelationships in the pathology, etiology, and prognosis of psychiatric disorders. A second purpose is to determine biological and psychological processes related to ANS activity and attention. ANS activity is assessed by peripheral measures, such as skin conductance, heart rate, and skin temperature. Subjects are tested under conditions of rest, presentation of tones, and performance on tasks such as reaction time and two-flash discrimination. Biological mechanisms are investigated by correlating these variables with enzyme activity, neuropeptides, and levels of biogenic amines and their metabolites. Studies are being done on unmedicated patients with diagnoses of schizophrenia, affective disorder, obsessive compulsive disorder, anxiety-panic disorder, and autism to test the diagnostic specificity of patterns of ANS activity. Effects of state changes are studied in cases of multiple personality, as well as with brain dysfunction as revealed by CT and PET scans. In some studies blood samples are taken during ANS recording sessions in which stressful procedures are given. In one, the effects of success and failure to escape an aversive noise are assessed, and in another, the effects of a dose of yohimbine is being studied. Clinical trials of various treatments are studied. These include pimozide, propranolol, verapamil, and hemodialysis in schizophrenia, clorgyline and clomipramine in obsessives, and alprazolam and imipramine in panic-anxiety patients. Psychological correlates are studied via clinical background data, clinical ratings and questionnaires, and by procedural variations. The use of confirmatory factor analysis in data reduction and to improve quantification of ANS activity is being explored.