LIPID PHYSICAL CHEMISTRY IN BIOLOGY AND PATHOLOGY

总体目标是应用物理化学原理和技术， 对涉及脂类的生理和病理过程的研究。 某些 生物流体（血浆、淋巴液、胆汁）含有溶解或悬浮的脂质 脂质在组织、细胞和体液中的病理分布。 等 可能导致动脉粥样硬化或胆结石等疾病。 的质膜 细胞和细胞内细胞器含有复杂的极性脂质， 可溶，但以结合联合收割机流动性和稳定性方式构成。 细胞器与细胞器之间的膜组成不同， 在脂质和蛋白质分布方面是不对称的。 膜 成分和不对称性可以通过外部环境的变化而改变 或通过内部代谢扰动，并且这种变化可能导致缺陷的 功能 遗传性缺乏酶参与的catalysis 复杂的磷脂和鞘脂导致未代谢的 细胞器、膜和溶酶体中的脂质。 这些积累 影响细胞和器官功能，并引起各种家族性过敏反应。 最后，某些极性较低的脂质（例如存在于脂肪中）， 组织、肾上腺、性腺、肝脏和动脉粥样硬化病变） 在从含水系统分离的相中含有脂质。 这些阶段可能是 液体或更结构化的液晶或结晶相。 长 学期目标是研究脂质的物理状态和分子间的相互作用 和蛋白质，将它们与模型系统进行比较， 身体状态影响新陈代谢，反之亦然，了解 正常脂质转运和膜功能的分子基础， 了解脂质积累条件的分子基础， 如动脉粥样硬化、脂蛋白血症和高脂血症。

The overall objective is to apply physical-chemical rationale and techniques to the study of physiological and pathological processes involving lipids. Certain biological fluids (plasma, lymph, bile) contain lipids solubilized or suspended into a pathological distribution of lipids in tissues, cells, and fluids. Such disorders as atherosclerosis or gallstones may result. The plasma membranes of cells and of intracellular organelles contain complex polar lipids which are not soluble but are structured in such a way as to combine fluidity with stability. Membrane composition varies from organelle to organelle and further membranes are asymmetric with respect to both lipid and protein distribution. Membrane composition and asymmetry can be altered by changes in the external environment or by internal metabolic perturbations and such changes may lead to defective function. Inherited deficiencis of enzymes involved in the catabolism of complex phospho- and sphingolipids result in the accumulation of unmetabolized lipids in cellular organelles, membranes and lysosomes. These accumulations affect cell and organ function and give rise to the various familial lipidoses. Finally, certain less polar lipids (occurring for instance in the adipose tissue, adrenal glands, gonads, liver and in the lesions of atherosclerosis) contain lipids in phases separated from the aqueous system. These phases may be liquid or more structured liquid crystalline or crystalline phases. The long term goals are to study the physical state and molecular interactions of lipids and proteins in living systems, to compare them to model systems, to learn how the physical state affects metabolism and vice versa, to understand the molecular basis of normal lipid transport and membrane function and ultimately to understand the molecular basis of conditions in which lipids accumulate, such as atherosclerosis, the lipoproteinemias, and the lipidoses.