Non-hospitalised Children & young people (CYP) with Long Covid (The CLoCk Study)

研究目的(S)：似乎有些儿童和青年(CYP)在感染COVID病毒后仍长期患病。据说它们有“长冠状病毒病”。类似的疾病可能发生在一种常见的儿童感染--腺热之后。医生不知道如何诊断慢性冠状病毒病，它有多常见，或者持续多长时间。对于长时间的COVID没有简单的测试。如果我们想治疗它，我们需要对它有更多的了解。这项研究的背景：对成年人的长期COVID或CYP知之甚少。在CYP中，COVID恶化的危险因素包括肥胖、既往疾病、学习障碍、脑部疾病、精神健康问题和来自少数民族。长期COVID的风险最大的可能是青少年，他们在其他病毒感染后更有可能出现持续性疲劳和心理健康问题。使用的设计和方法：我们将接近30,000名CYP，其中一半我们知道患有COVID。我们预计会有6000人同意帮助我们，我们会在3个月、6个月、12个月和24个月后询问他们是否仍有身体或精神问题。我们可以将3000名COVID检测呈阳性的应答者与3000名未检测呈阳性的应答者进行比较。然后我们就可以就什么是长冠状病毒病的医学诊断以及我们可能如何治疗达成一致。D.患者和公众的参与：(PPI)：我们将有一个付费的PPI负责人，他将确保与护理人员和CYP共同制作。我们也会使用一些资金来鼓励忙碌的照顾者和CYP给他们宝贵的时间来完成调查S.E.完全透明：我们将尽快免费与任何想要查看的人分享我们的所有结果，特别是参与其中的CYP。

a. aim(s) of the research: It seems that some children and young people (CYP) remain ill for a long time after infection with COVID virus. They are said to have ‘long COVID’. Something similar can follow a common childhood infection called glandular fever. Doctors don’t know how to diagnose long COVID, how common it is or how long it goes on for. There is no simple test for long COVID. We need to know more about it if we want to treat it. b. background to the research: Little is known about long COVID in adults or CYP. Risk factors for worse COVID in CYP include obesity, pre-existing diseases, learning disabilities, diseases of the brain, mental health problems and coming from an ethnic minority. The CYP likely to be most at risk of long COVID are teenagers who are more at risk of persistent fatigue and mental health problems after other viral infections. c. design and methods used: We will approach 30,000 CYP, half of whom we know had COVID. We expect 6,000 to agree to help us and we will ask them whether they still have physical or mental problems at 3, 6,12 and 24 months afterwards. We can compare the 3,000 responders who had a positive COVID test with the 3,000 responders who didn’t test positive. We can then agree on what is a medical diagnosis of long COVID and how we might treat it. d. patient and public involvement: (PPI): We will have a paid PPI lead who will ensure co-production with carers and CYP. We will also use some funds to encourage busy carers and CYP to give their valuable time to complete the survey s.e. Complete transparency: We will share all our results ASAP for free with anyone who wants to see them, especially the CYP who take part.