Therapies for Long COVID in non-hospitalised individuals: From symptoms, patient-reported outcomes and immunology to targeted therapies (The TLC Study)

非住院个体的长期新冠肺炎治疗：从症状、患者报告的结果和免疫学到靶向治疗（TLC 研究）

• 批准号: MC_PC_20050
• 负责人: Shamil Haroon
• 金额: $ 143.8万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_20050
• 关键词: Therapies; Long; COVID; non; hospitalised

Background: Some people who have survived COVID-19 infection develop longer-lasting symptoms, known as Long COVID. Many lack support and are given conflicting advice. Aim: To work out which treatments are most likely to benefit people with particular symptoms and test supportive treatments to improve their quality of life. Design and methods Work package 1 will identify people that had COVID-19 from GP records. Study participants will be invited to use a digital platform to report Long COVID symptoms/quality of life. Work package 2 will assess Long COVID symptoms. Participants with severe symptoms will be contacted by a nurse to provide advice/support. Blood test results and wearable data will help us understand which treatments might be best to support specific groups of Long COVID patients. Work package 3 will review evidence for treatments for Long COVID including drugs or supportive interventions (e.g. for mental health or tiredness). Working with patients, doctors and other experts we will recommend treatments that should be tested in Long COVID patients and develop supportive interventions which can be delivered using the Long COVID platform. Work package 4 will establish a digital trial using the Long COVID platform to test whether supportive interventions can benefit Long COVID patients by reducing their symptoms and improving their quality of life and if the intervention is good value for money. Patient and public involvement People with COVID lived experience have co-designed this research proposal and the research platform. A lived experience advisory panel will work with us throughout the project and meet regularly to contribute to all aspects of the study. Dissemination Results will be published, presented at conferences and made available for use by other researchers. We will host a study specific website and Twitter account and will share lay summaries coproduced with our patient partners.

背景：一些在COVID-19感染中幸存下来的人会出现持续时间更长的症状，称为长期COVID。许多人缺乏支持，得到的建议相互矛盾。目的：找出哪些治疗方法最有可能使患有特定症状的人受益，并测试支持性治疗方法以改善他们的生活质量。设计和方法工作包1将从全科医生记录中识别出患有COVID-19的人。将邀请研究参与者使用数字平台报告长期COVID症状/生活质量。工作包2将评估长期COVID症状。护士将联系症状严重的受试者，提供建议/支持。血液检测结果和可穿戴数据将帮助我们了解哪些治疗方法可能最适合支持特定的长期COVID患者群体。工作包3将审查长期COVID治疗的证据，包括药物或支持性干预措施（例如心理健康或疲劳）。我们将与患者、医生和其他专家合作，推荐应在Long COVID患者中进行测试的治疗方法，并开发可使用Long COVID平台提供的支持性干预措施。工作包4将使用Long COVID平台建立一项数字试验，以测试支持性干预措施是否能通过减轻症状和改善生活质量使Long COVID患者受益，以及干预措施是否物有所值。患者和公众参与有COVID生活经验的人共同设计了这个研究方案和研究平台。一个生活经验咨询小组将在整个项目中与我们合作，并定期开会，为研究的各个方面做出贡献。传播结果将发表，在会议上介绍，并提供给其他研究人员使用。我们将建立一个研究专用网站和Twitter账户，并与我们的患者合作伙伴分享共同制作的非专业摘要。

项目成果

Digitally enabled decentralised research: opportunities to improve the efficiency of clinical trials and observational studies.

以数字化的能力分散研究：提高临床试验和观察性研究效率的机会。

• DOI: 10.1136/bmjebm-2023-112253
• 发表时间: 2023-10
• 期刊: BMJ EVIDENCE-BASED MEDICINE
• 影响因子: 5.8
• 作者: Aiyegbusi, Olalekan Lee;Davies, Elin Haf;Myles, Puja;Williams, Tim;Frost, Chris;Haroon, Shamil;Hughes, Sarah E.;Wilson, Roger;McMullan, Christel;Subramanian, Anuradhaa;Nirantharakumar, Krishnarajah;Calvert, Melanie J.
• 通讯作者: Calvert, Melanie J.

Therapies for Long COVID in non-hospitalised individuals: from symptoms, patient-reported outcomes and immunology to targeted therapies (The TLC Study).

• DOI: 10.1136/bmjopen-2021-060413
• 发表时间: 2022-04-26
• 期刊: BMJ OPEN
• 影响因子: 2.9
• 作者: Haroon, Shamil;Nirantharakumar, Krishnarajah;Hughes, Sarah E.;Subramanian, Anuradhaa;Aiyegbusi, Olalekan Lee;Davies, Elin Haf;Myles, Puja;Williams, Tim;Turner, Grace;Chandan, Joht Singh;McMullan, Christel;Lord, Janet;Wraith, David C.;McGee, Kirsty;Denniston, Alastair K.;Taverner, Thomas;Jackson, Louise J.;Sapey, Elizabeth;Gkoutos, George;Gokhale, Krishna;Leggett, Edward;Iles, Clare;Frost, Christopher;McNamara, Gary;Bamford, Amy;Marshall, Tom;Zemedikun, Dawit T.;Price, Gary;Marwaha, Steven;Simms-Williams, Nikita;Brown, Kirsty;Walker, Anita;Jones, Karen;Matthews, Karen;Camaradou, Jennifer;Saint-Cricq, Michael;Kumar, Sumita;Alder, Yvonne;Stanton, David E.;Agyen, Lisa;Baber, Megan;Blaize, Hannah;Calvert, Melanie
• 通讯作者: Calvert, Melanie

Non-pharmacological therapies for postviral syndromes, including Long COVID: a systematic review and meta-analysis protocol.

• DOI: 10.1136/bmjopen-2021-057885
• 发表时间: 2022-04-11
• 期刊: BMJ OPEN
• 影响因子: 2.9
• 作者: Chandan, Joht Singh;Brown, Kirsty;Simms-Williams, Nikita;Camaradou, Jenny;Bashir, Nasir;Heining, Dominic;Aiyegbusi, Olalekan Lee;Turner, Grace;Cruz Rivera, Samantha;Hotham, Richard;Nirantharakumar, Krishnarajah;Sivan, Manoj;Khunti, Kamlesh;Raindi, Devan;Marwaha, Steven;Hughes, Sarah E.;McMullan, Christel;Calvert, Melanie;Haroon, Shamil
• 通讯作者: Haroon, Shamil

Symptoms, complications and management of long COVID: a review.

• DOI: 10.1177/01410768211032850
• 发表时间: 2021-09
• 期刊: Journal of the Royal Society of Medicine
• 影响因子: 17.3
• 作者: Aiyegbusi OL;Hughes SE;Turner G;Rivera SC;McMullan C;Chandan JS;Haroon S;Price G;Davies EH;Nirantharakumar K;Sapey E;Calvert MJ;TLC Study Group
• 通讯作者: TLC Study Group

Core outcome measurement instruments for use in clinical and research settings for adults with post-COVID-19 condition: an international Delphi consensus study

用于 COVID-19 后成人临床和研究环境的核心结果测量工具：一项国际德尔菲共识研究

• DOI: 10.1016/s2213-2600(23)00370-3
• 发表时间: 2023
• 期刊: The Lancet Respiratory Medicine
• 作者: Gorst S