MULTIPURPOSE ARTHRITIS CENTER

该提案详细描述了一项扩大和加强 波士顿大学多功能关节炎中心。一项活动计划 具体项目将分三个主要部分进行：研究、 教育和社区/卫生服务研究。该提案还包括 描述了一项计划，通过以下方式支持具有特殊研究兴趣的领域 两个核心单位，并继续有效的行政部门。 研究部分将建立在由以下方面资助的强大工作基础上 其他消息来源。此外，四项发展和可行性研究是 建议：1)前白蛋白形式的维生素A代谢的研究 淀粉样变性；2)血清淀粉样蛋白A基因克隆的分离；3)A 关节炎患者爬楼梯情况的调查；4)一项关于 功能评估中的难度维度。 Mac教育工作将继续针对广泛的 关节炎健康专业人员与医学院合作， 波士顿大学护理与专职卫生专业。特定的 教育部分的项目将包括对 内科风湿病住院医师教育现状分析 医学和家庭实践住院医师计划，一项关于 有针对性的理疗人际交往技能训练方案 大学生与慢性关节炎应对方式的调查研究。 陆委会社区/高铁部分的活动将继续侧重于 关于市中心社区与卫生署的合作 和波士顿市立医院。七个特定的社区/健康 提出了服务研究项目：1)修改 用于临床实践的关节炎影响测量量表；2)a 为临床开发以计算机为基础的社区网络的项目 风湿病试验；3)市内养老院项目结合 针对这一重要人群的外联和数据收集；4)研究 普通内科医生及其家属的风湿病转诊行为 从业者；5)骨性关节炎的流行病学研究 与弗雷明翰心脏研究；6)口腔疾病的流行病学研究 避孕药和类风湿性关节炎与已建立的 毒品流行病学组；(7)关系调查 类风湿关节炎的应激性生活事件与疾病活动性之间的关系。 提出了两个核心单元：一个淀粉样蛋白研究核心单元和一个研究 和评价支助核心股。这些核心单元将支持众多 对本中心特别感兴趣的领域进行调查。

This proposal describes in detail a plan to expand and strengthen the Boston University Multipurpose Arthritis Center. A program of activities and specific projects will be pursued in 3 major components: Research, Education and Community/Health Services Research. The proposal also describes a plan to support areas of special research interest by means of two Core Units, and to continue an effective Administration Component. The Research Component will build on a strong base of work funded from other sources. In addition, four Developmental and Feasibility studies are proposed: 1) a study of vitamin A metabolism in prealbumin forms of amyloid disease; 2) the isolation of cDNA clones for serum amyloid A; 3) an investigation of stair climbing in arthritis; and 4) a study of the difficulty dimension in functional assessments. MAC education efforts will continue to be aimed at a broad spectrum of arthritis health professionals in conjunction with the Schools of Medicine, Nursing and Allied Health Professions of Boston University. Specific projects in the education component will include an evaluation of the current status of house officer education in rheumatology at internal medicine and family practice residency programs, a study of the effects of a targeted training program on interpersonal skills of physical therapy students and an investigation of coping in chronic arthritis. Activities in the Community/HSR component of the MAC will continue to focus on the inner-city community in conjunction with the Department of Health and Hospitals of the City of Boston. Seven specific community/health services research projects are proposed: 1) a project to modify the Arthritis Impact Measurement Scales for use in clinical practice; 2) a project to develop a computer-based community network for clinical rheumatology trials; 3) a inner-city nursing home project combining outreach and data collection for this important population; 4) a study of the rheumatology referral behavior of general internists and family practitioners; 5) an epidemiologic study of osteoarthritis in conjunction with the Framingham Heart Study; 6) an epidemiologic study of oral contraceptives and rheumatoid arthritis in conjunction with an established drug epidemiology group; and (7) an investigation of the relationship between stressful life events and disease activity in rheymatoid arthritis. Two Core Units are proposed: an Amyloid studies Core Unit and a Research and Evaluation Support Core Unit. These Core Units will support numerous investigations in areas of special interest to this Center.