Interim support for ISARIC4C Clinical Characterisation Protocol (CCP) activation for acute severe hepatitis in children of unknown cause

在英国和世界各地，许多年幼的孩子正在发展严重的急性肝炎。事故原因尚不清楚。我们是一群医生和科学家，他们与公共卫生机构密切合作，对疫情进行研究。因为我们的研究（称为ISARIC4C）已经在全国范围内建立，我们可以在各地招募患者，整理数据和样本，并获得研究和开发的同意。ISARIC4C方法带来了学术部门的可扩展能力和尖端能力，以帮助国家及时应对公共卫生挑战，从而取得不同的成果。我们已经通过读取患有这种疾病的儿童血液和肝脏样本中的病毒DNA序列，为这种疾病的潜在病因——一种常见病毒的组合——提供了最有力的证据。我们已经制定了一项快速研究计划，以解决英国公共卫生机构确定的关键问题。要做到这一点，我们需要做的第一件事是招募患者和他们的家人参与研究，寻找疾病的原因，了解免疫系统的作用，找到可能解释疾病过程的遗传因素，并提出新的治疗方法。

A number of young children in the UK, and across the world, are developing severe acute hepatitis. The cause is unknown. We are a group of doctors and scientists who do research in outbreaks in close partnership with public health agencies. Because our study (called ISARIC4C) is already set up across the whole country, we can recruit patients everywhere, collate data and samples and gain consent for research and development. The ISARIC4C approach brings the scalable capacity and cutting-edge capabilities of the academic sector to help the nation respond to public health challenges in time to make a difference to outcome. We have already shown the strongest evidence for the underlying cause of this disease - a combination of common viruses - by reading the DNA sequence of viruses in samples of blood and liver from children with the disease.We have put together a rapid research plan to tackle the key questions identified by UK public health agencies. To do this, the first thing we need to do is recruit patients and their families into research studies to look for the cause of the disease, understand the role of the immune system, find genetic factors that may explain the disease processes, and suggest new treatments.