ManGO: Manchester Global Omics Initiative for Nutritional Health

营养是低收入和中等收入国家面临的许多健康挑战的基础。从历史上看，营养不足一直是主要问题，对生长和发育、感染易感性和治疗反应等产生明显影响。除了营养不良造成的健康问题外，发展中国家还面临着全球化和文化变革带来的新的营养挑战，面临着所谓的“营养转型”。社会经济因素的不平等、气候变化、粮食不安全和获得保健服务的机会不一，使这一新出现的情况更加复杂。营养影响人类福祉的潜在临床领域非常广泛。结合尖端的分析和生物科学以及数据的计算分析将导致对分子营养及其对LMIC健康和疾病影响的新理解，特别是通过整合这些方法。这个泵启动项目建立在曼彻斯特大学研究小组的现有优势基础上，并将与印度和南非的合作伙伴建立密切联系，将营养和临床科学的关键方面联系起来。我们将推进营养研究在这些环境中未来可以发挥重要作用的新领域，主要是通过建立健康数据科学和尖端实验室研究方法与复杂计算技术的更紧密结合。我们的目标是建立密切的合作关系，为下一阶段创造新的协同作用和质量更好的研究环境。我们将探索的领域对当地人口健康特别重要：怀孕和早期发育中的营养;儿童生长营养和传染病营养和新出现的非传染性疾病，如过敏拟议的12个月发展计划将侧重于扩展现有网络和创建新网络。合作伙伴之间将进行访问，沿着一系列研讨会和其他活动，以确定未来的研究机会和要解决的关键研究问题。我们还将开展试点研究工作（最初侧重于儿童发育和结核病中的营养因素），以开发必要的工具，并确保拟议的主题适用于未来的重大赠款申请，特别是在“全球挑战研究基金”竞技场。预期的影响将是发展和开展世界级的营养和健康合作研究，建设我们合作机构的研究能力。我们计划继续在基础科学和人类健康和疾病营养的临床方面成功地进行研究资助。

Nutrition underpins many of the health challenges faced by low and middle income countries. Historically, under-nutrition has been the dominant problem, with clear impacts, e.g. on growth and development, and on susceptibility to infection and responses to therapy. As well as health problems caused by under-nutrition, developing countries are facing new nutritional challenges due to globalisation and cultural change, facing the so-called "nutrition-transition". This emerging situation is compounded by inequalities in socioeconomic factors, by climate change, by food insecurity and by variable access to health provision. The potential range of clinical areas in which nutrition affects human welfare is extremely wide.Coupling cutting-edge analytical and biological sciences and computational analysis of data will lead to a new understanding of molecular nutrition and its impacts on health and disease in LMICs, especially by integrating these approaches.This pump-priming project builds upon existing strengths in research groups at the University of Manchester, and will develop strong links to partners in India and South Africa connecting key aspects of nutritional and clinical sciences. We will advance new areas where nutritional research can play a major future role in these settings, principally by establishing a closer integration of health data sciences, and cutting-edge laboratory based approaches to research coupled to sophisticated computational techniques. Our aim is in building close collaborations that create new synergies and qualitatively better research environments for the next phase.The areas we will explore are of particular importance to local population health:Nutrition in pregnancy and early development; childhood growthNutrition and infectious disease Nutrition and emerging non-communicable diseases e.g. allergyThe proposed 12-month developmental plan will focus on extending existing networks and creating new ones. Visits will be made between the partners, along with a series of workshops and other events to define future research opportunities and the key research questions to be addressed. We will also undertake pilot research work (initially focussed on nutritional factors in childhood development and in tuberculosis) to develop the necessary tools and to ensure that the proposed topics are feasible for future major grant applications, especially in the 'Global Challenges Research Fund' arena.The expected impact will be the development and conduct of world class collaborative research in nutrition and health, building research capacity in our partner institutions. We plan to follow on by successful research funding bids in basic science and clinical aspects of human nutrition in health and disease.