Methodological issues in dementia epidemiology

这项合作奖的目的是建立百万妇女研究，由牛津大学MRC资助的队列研究和哈佛T.H.痴呆症研究专家之间的合作。陈博士公共卫生学院及美国马萨诸塞州总医院。申请人Floud博士是一位早期职业流行病学家，致力于研究百万女性研究队列中痴呆症的生活方式风险因素。百万女性研究始于20年前，招募了130万名女性，每4名出生于1935-1950年的英国女性中就有1名。它仍然通过与常规收集的NHS数据库的电子链接跟踪99%的幸存者入院和死亡。因此，它是一个独特的资源，可以研究中年因素，这些因素可能会增加老年痴呆症的风险，以及那些可能预防痴呆症的因素。弗劳德博士计划访问美国，在一个研讨会上与布莱克教授会面，并在哈佛T. H. Floud博士建议与Blacker教授合作，Blacker教授是一位老年精神病学家和流行病学家，在痴呆症流行病学方面有着悠久的研究历史。她接受美国国立卫生研究院的资助。她在马萨诸塞州阿尔茨海默病研究中心共同领导临床研究，并担任哈佛大脑老化研究的首席研究员。布莱克教授也是哈佛大学流行病学系副主任。陈公共卫生学院，弗劳德博士的访问将在那里进行。是次访问的目的是（i）让Floud博士了解在临床和研究环境中对轻度认知障碍和痴呆症的诊断。这将是通过观察教授布莱克在工作中的质量综合医院和她的同事们在诊断认知障碍和痴呆症和痴呆症的亚型（如阿尔茨海默氏病或血管性痴呆症）的识别工作会议;（ii）弗劳德博士学习更多关于检测和占偏见和混淆痴呆症的流行病学研究的方法。这将通过与哈佛公共卫生学院的Blacker教授及其同事会面来实现;（iii）Floud博士与Blacker教授合作分析百万妇女研究的数据，研究从事智力活动对延迟或预防痴呆症的预防作用。

The aim of this partnering award is to establish a collaboration between the Million Women Study, an MRC-funded cohort study run by the University of Oxford, and experts in dementia research at the Harvard T.H. Chan School of Public Health and Massachusetts General Hospital in the US. The applicant Dr Floud is an early career epidemiologist working on research into lifestyle risk factors for dementia in the Million Women Study cohort. The Million Women Study began 20 years ago, recruiting 1.3 million women, 1 in every 4 UK women born in 1935-1950. It still follows 99% of survivors for hospital admissions and deaths by electronic linkage to routinely collected NHS databases. As such it is a unique resource in which to study the factors in midlife that might increase the risk of dementia later in life and those that might prevent dementia. Dr Floud plans to visit the US to meet Professor Blacker at a workshop and also for a two-week visit to the Harvard T.H. Chan School of Public Health.Dr Floud proposes to collaborate with Professor Blacker, who is a geriatric psychiatrist and epidemiologist, with a long history of research on the epidemiology of dementia. She receives funding from the National Institutes of Health in the US. She jointly leads clinical research in the Massachusetts Alzheimer's Disease Research Center and is a lead investigator for the Harvard Aging Brain Study. Prof Blacker is also Deputy Chair of the Department of Epidemiology at the Harvard T.H. Chan School of Public Health, where Dr Floud's visit will take place. The objectives of the visit are(i) for Dr Floud to learn about the diagnosis of mild cognitive impairment and dementia in a clinical and research setting. This will be achieved by observing Prof Blacker at work in the Mass General Hospital and meeting with her colleagues working on diagnosing cognitive impairment and dementia and on the identification of the subtypes of dementia (eg Alzheimer's disease or vascular dementia);(ii) for Dr Floud to learn more about methods for detecting and accounting for bias and confounding in epidemiological studies of dementia. This will be achieved by meeting with Professor Blacker and her colleagues at the Harvard School of Public Health; (iii) for Dr Floud to collaborate with Professor Blacker in an analysis of data from the Million Women Study on the proposed protective effect of engaging in intellectual activities in delaying or preventing the onset of dementia.