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Definition and Caregiver Appraisal of Paradoxical Lucidity in Dementia

痴呆症中矛盾清醒的定义和护理人员评估

基本信息

批准号：
10092367
负责人：
JOAN M. GRIFFIN
金额：
$ 23.52万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-30 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10092367
关键词：
Address Advocacy Affect Age Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Anecdotes Awareness Behavior Bereavement Brain Health Registry Caregiver well-being Caregivers Case Study Cessation of life Characteristics Clinical Cognitive Communication Conflict (Psychology)Consensus Data Dementia Dementia caregivers Development Dimensions Disease Education Ensure Ethical Issues Event Family Family Caregiver Family member Future Geography Goals Grief reaction Health Impaired cognition Incidence Individual Internet Intervention Interview Knowledge Link Long-Term Care Longitudinal Surveys Measures Memory Methodology Methods Minnesota Mission Moods Nonprofit Organizations Outcome Outcome Study Pattern Persons Pharmaceutical Preparations Phase Prevalence Registries Reporting Research Structure Surveys Testing Time Typology Universities Work advocacy organizations base care giving burden caregiver bereavement caregiver interventions caregiving clinical practice cognitive capacity demographics education resources epidemiology study evidence base experience innovation longitudinal analysis novel outcome forecast perceived stress psychoeducation response sex

项目摘要

PROJECT SUMMARY Alzheimer’s disease and related dementias are typically thought of in terms of progressive cognitive decline, and relatively little is known about episodes of lucidity that occur among people with dementia. Paradoxical lucidity is defined as spontaneous, relevant communication or connectedness in a person with dementia. Few studies have focused on paradoxical lucid episodes, and little is known about what may cause paradoxical lucidity, how common lucid events are, and how lucidity impacts family caregivers of persons with dementia. The broad goal of this study is to define paradoxical lucidity, determine the prevalence and predictors of paradoxical lucidity, and assess the impact that lucidity has on family caregivers. Our proposal will establish a definition of paradoxical lucidity based on survey data and interviews with caregivers, as well as input from a panel of clinical experts in Alzheimer’s disease and related dementias. Next, we will administer an online survey to 8,000 dementia caregivers across three time periods (baseline, 6-months, and 12-months) to measure how frequently paradoxical lucidity occurs across time. We will analyze survey data to establish what may predict paradoxical lucidity and how paradoxical lucidity is linked to caregiver well-being. The results of this work will help inform clinical practice, build capacity for Alzheimer’s Disease education and advocacy, and build knowledge on an understudied aspect of dementia.

项目摘要阿尔茨海默病和相关痴呆症通常被认为是进行性认知衰退，而对于痴呆症患者的清醒期，我们所知相对较少。矛盾清醒被定义为痴呆症患者自发的、相关的沟通或连通性。几研究集中在矛盾的清醒发作，很少有人知道什么可能导致矛盾的清醒，清醒事件有多常见，以及清醒如何影响痴呆症患者的家庭照顾者。本研究的主要目标是定义矛盾清醒，确定其患病率和预测因素，矛盾的清醒，并评估清醒对家庭照顾者的影响。我们的建议将建立一个根据调查数据和对照顾者的采访，以及来自一个阿尔茨海默病和相关痴呆症的临床专家小组。接下来，我们将管理在线在三个时间段（基线、6个月和12个月）对8，000名痴呆症护理人员进行调查，测量一段时间内出现矛盾清醒的频率。我们将分析调查数据，可以预测矛盾的清醒和矛盾的清醒是如何与照顾者的幸福。的结果这项工作将有助于为临床实践提供信息，建立阿尔茨海默病教育和宣传的能力，建立对痴呆症未充分研究方面的知识。