Early Life Aetiology and Mechanisms of Diabetes and Related Metabolic Disorders

该方案的目的是通过确定在婴儿期起作用的遗传、饮食和其他因素，预测和预防儿童肥胖症。具体目标是确定可预测儿童肥胖的遗传因素和早期婴儿饮食和生长模式，并制定和测试干预措施，以避免婴儿体重过度增加和儿童肥胖。|儿童肥胖是一个重大的公共卫生问题。研究很重要，因为1）目前还没有经过证实的干预措施来预防儿童肥胖，2）即使在幼儿中，肥胖率也在上升，3）儿童肥胖对儿童健康和发育以及成人健康都有重要影响。|这项研究正在英国的一些出生队列研究中进行，包括与雅芳父母和儿童纵向研究（ALSPAC），南安普顿妇女研究（SWS）和剑桥婴儿生长研究（MRC流行病学单位和剑桥大学儿科系）的密切合作。在儿童中收集的DNA样本中研究的候选遗传因子是由桑格研究所和剑桥大学能量与代谢遗传学（GEM）财团合作选择的。儿童肥胖及其并发症风险的预测模型将基于来自英国和国际出生队列研究的研究人员之间的合作研究。|将通过招募怀孕期间的母亲进行随机对照试验，以测试避免婴儿过量营养摄入的教育是否会防止婴儿体重快速增加和儿童肥胖风险。未来将制定有针对性的干预措施，用于在被确定为儿童肥胖高风险的婴儿和幼儿中进行测试。

The aim of this programme is to predict and prevent childhood obesity by identifying genetic, dietary and other factors that act during infancy. The specific objectives are to identify genetic factors and patterns of early infant diet and growth that predict childhood obesity, and to develop and test interventions to avoid excessive infant weight gain and childhood obesity. |Childhood obesity is a major public health problem. Research is important because 1) currently there are no proven interventions to prevent childhood obesity, 2) rates of obesity are rising even in young children, 3) childhood obesity has important consequences for childhood health and development, as well as adult health.|This research is being performed in a number of UK birth cohort studies, including close collaborations with the Avon Longitudinal Study of Parents and Children (ALSPAC), the Southampton Womens Study (SWS), and the Cambridge Baby Growth Study (MRC Epidemiology Unit & Department of Paediatrics, University of Cambridge). Candidate genetic factors for study in DNA samples collected in children are selected by in collaboration with the Sanger Institute and University of Cambridge Genetics of Energy & Metabolism (GEM) consortium. Prediction models for risk of childhood obesity and its complications will be based on collaborative studies between investigators from a wide range of UK and international birth cohort studies. |A randomised controlled trial will be performed by recruiting mothers during pregnancy to test whether education to avoid excess infant nutrient intake will prevent rapid infant weight gain and childhood obesity risk. Future targeted interventions will be developed for testing in infants and young children identified to have high risk of childhood obesity.