GENERAL CLINICAL RESEARCH CENTER

此应用程序寻求为期五年的普通临床支持 研究中心将设在圣安东尼奥，目前圣安东尼奥是世界第九大城市 是美国城市，是200-300万人的转介中心 住在南得克萨斯州的人。这个临床研究机构将 由12张床位组成，将设在塔河特殊诊断和 奥迪·L·墨菲纪念退伍军人管理局的治疗单位 医院，德克萨斯大学健康科学大学的教学医院 圣安东尼奥中心，与医学院毗邻。这个 现有的设施已经包括床位、护士、实验室空间， 设备、营养师和饮食辅助设备，以及办公室、厨房和会议 综合临床研究中心所需的房间空间。这 当前的应用程序旨在提供一种执行以下操作的机制 该院非退伍军人和退伍军人的临床研究 这样一种最大限度地利用现有资源的方式。这笔赠款 适用于临床研究中的多学科项目 涉及内科、儿科、精神科、产科 以及妇科和药理学。本提案中的42项协议包括 肿瘤中的钙、磷和骨代谢 疾病，腺苷脱氨酶缺乏症和免疫缺陷病， 巴特综合征的病理生理、发病机制及治疗 影响青春期生长发育的因素--高血压 治疗肿瘤疾病的新药物和新方法，钾和 肾脏疾病的酸碱平衡、正常和正常的凝集素受体 人类肿瘤淋巴细胞，抑郁症的心理生物学和 食道动力。

This application seeks support for five years for a General Clinical Research Center to be situated in San Antonio, which is now the 9th largest city in the United States and is the referral center for the 2-3 million people who live in South Texas. This clinical research facility will consist of 12 beds and will be located in tahe Special Diagnostic and Treatment Unit at the Audie L. Murphy Memorial Veterans' Administration Hospital, a teaching hospital of the University of Texas Health Science Center at San Antonio which is contiguous with the medical school. The current facility already contains the beds, nurses, laboratory space, equipment, dietitian and dietary aids, and office, kitchen and conference room space which is necessary for a General Clinical Research Center. This current application is designed to provide a mechanism for performing clinical reserach on non-veterans as well as veterans in this facility in such a way as to make maximal use of existing resources. This grant application is for a multi-disciplinary program in clinical research involving the Departments of Medicine, Pediatrics, Psychiatry, Obstetrics and Gynecology and Pharmacology. The 42 protocols in this proposal cover areas such as calcium, phosphorus and bone metabolism in neoplastic disease, adenosine deaminase deficiency and immunodeficiency disease, the pathophysiology of Bartter's Syndrome, pathogenesis and treatment of essential hypertension, factors influencing growth at puberty, development of new agents and methods for treating neoplastic disease, potassium and acid-base balance in renal disease, lectin receptors on normal and neoplastic human lymphocytes, the psychobiology of depression and esophageal motility.