Intrinsic Immunity

格拉斯哥大学mrc -大学病毒研究中心（CVR）首席研究员Chris Boutell博士蛋白质的修饰调节了细胞生物学的许多重要方面，包括宿主对感染的免疫力。因此，病毒进化出了利用或抑制调节蛋白质修饰的途径来克服宿主对感染的防御的策略，从而增强了它们的复制、传播和疾病负担。然而，在生化水平上，这些关键的相互作用在很大程度上仍未定义。该计划的工作重点是两种途径，即泛素和SUMO（小泛素样修饰物），我们和其他人已经证明它们在调节宿主免疫中发挥重要作用。我们的目的是确定影响感染结果的核心酶的活性，使用单纯疱疹病毒1 （HSV-1）作为模型DNA病毒。这些研究将揭示在DNA病毒感染期间调节宿主免疫的机制的独特见解，以及揭示调节与人类疾病相关的其他重要细胞生物学领域的基本原理，例如致癌作用。通过了解这些原理，我们的目标是为未来的治疗干预开发新的靶向方法，以治疗与公共卫生相关的病毒感染。

Dr Chris Boutell, Lead Investigator, MRC-University of Glasgow Centre for Virus Research (CVR), University of GlasgowThe modification of proteins regulates many important aspects of cell biology, including host immunity to infection. Viruses have therefore evolved strategies to utilise or suppress pathways that regulate protein modification to overcome host defences to infection, thereby enhancing their replication, spread, and disease burden. However, these key interactions remain largely undefined at a biochemical level. Work within this programme focuses on two pathways, namely ubiquitin and SUMO (Small Ubiquitin-like MOdifier), which we and others have shown to play an important role in the regulation of host immunity. Our aim is to define the activity of core enzymes that influence the outcome of infection, using herpes simplex virus 1 (HSV-1) as a model DNA virus. These studies will reveal unique insight into the mechanisms that regulate host immunity during DNA virus infection, as well as uncovering fundamental principles that regulate other important areas of cell biology relevant to human disease, for example carcinogenesis. By understanding these principles we aim to develop new targeted approaches for future therapeutic intervention to treat viral infections pertinent to public health.