TOXICANTS IN HUMAN PLACENTA AND REPRODUCTIVE OUTCOMES IN UKRAINE

在新独立的乌克兰，环境污染是 严重；污染不仅是由于切尔诺贝利事故，而且 到集约化农业实践和过时的工业技术。 这项初步研究的目的是描述毒物的负担。 在这种情况下分娩的妇女的胎盘和乳汁中， 并记录它们的繁殖结果。据我们所知，这是 首次对前者的妊娠结局进行基于人群的描述 苏联国家。 为了实现这些目标，我们正在与乌克兰合作 “ELSPAC”研究--世界首创的几项欧洲研究之一 卫生组织。我们已经获取了胎盘和牛奶样本 2000多名妇女在两个研究地点分娩并将其储存起来 未来的分析。妊娠结局的完整记录是 正在获取；到目前为止，已提取了1000条记录。毛收入 所有的胎盘都做了病理和形态测量。双语 代码本已经写好了。我们很快就会授予一份合同来完成 收集数据并进行方法学检查，另一项开始化验 生物样本中的。

In the newly independent country of Ukraine, environmental pollution is severe; the contamination is due not only to the Chernobyl accident, but to intensive agricultural practices and outmoded industrial technology. The purpose of this pilot study is to describe the burden of toxicants in placentas and milk of women who deliver infants in such circumstances, and to document their reproductive outcome. To our knowledge, this is the first population-based description of pregnancy outcome in a former Soviet country. To accomplish these aims, we are collaborating with the Ukrainian "ELSPAC" study, one of several European studies initiated by the World Health Organization. We have obtained placenta and milk samples from over 2,000 women who delivered in two study sites and stored them for future analysis. A complete record of the outcome of the pregnancy is being obtained; to date, 1000 records have been abstracted. Gross pathology and morphometrics have been done for all placentas. Bilingual codebooks have been written. We will soon award a contract to complete data gathering and conduct methology checks, and another to begin assays of the biological samples.