Understanding infectious laryngotracheitis virus recombination

本项目将研究导致传染性喉气管炎病毒（ILTV）毒株之间重组并增加毒力的因素。在先前的ILTV研究中，两种新的毒力野毒株基因型被证明是从不同的ILTV减毒商业疫苗衍生的独立重组体。这些毒株成为导致澳大利亚家禽广泛和严重疾病暴发的主要野地病毒。该项目将加强对导致这些有害自然重组事件的条件的了解，并使行业能够避免未来出现新的有毒现场菌株。

This project will study the factors that lead to recombination between strains of infectious laryngotracheitis virus (ILTV) concomitant with increased virulence. In previous studies of ILTV, two new genotypes of virulent field strains were shown to be independent recombinants derived from distinct attenuated ILTV commercial vaccines. These strains became the dominant field viruses responsible for widespread and severe disease outbreaks in Australian poultry flocks. This project will enhance understanding of the conditions that led to these deleterious natural recombination events and enable the industry to avoid the emergence of new virulent field strains in the future.