Determining the mechanistic basis of the patterns of inverse drug susceptibility induced by two key drug resistance proteins of the malaria parasite.

许多病原体和癌症对新药产生抗药性的无穷无尽的能力是对世界健康的严重威胁。然而，在对一种药物产生抗药性的过程中，许多病原体和癌细胞对一种或多种其他药物变得高度敏感。我们试图阐明疟疾寄生虫中这种现象的几个分子机制。从这项工作中获得的见解将有助于制定克服或延缓耐药性的新治疗策略。

The inexhaustible capacity of many pathogens and cancers to develop resistance to new drugs is a serious threat to world health. Yet in acquiring resistance to one drug, many pathogens and cancer cells become hypersensitive to one or more other drugs. We seek to elucidate several of the molecular mechanisms underpinning this phenomenon in the malaria parasite. Insights gained from this work will contribute to the formulation of new therapeutic strategies that overcome or retard drug resistance.