A PROBE-BASED SYSTEM FOR ASSESSING PRESYNAPTIC NEURONAL DAMAGE

破坏特定神经元的环境毒素的存在会引起 某些人类神经退行性疾病可能是 环境因素。简易型与非整体型的开发与应用 可以评估脑神经化学变化的侵入性方法将 是研究暴露在环境中的人群的重要一步 神经毒素。 该项目的总体目标是验证和评估 一种简单的非侵入性符合探测器系统的有用性(双 探针)，用于使用正电子发射测量神经元标志物 放射性配基。突触前和突触后神经元的研究 将在正常人和实验动物身上进行标记 模特以及接触环境或职业环境的人 神经毒素。 在长期接触环境毒素的人中，这些神经化学物质 测量也许能够发现中枢神经系统的早期征兆。 在行为或临床表现之前的损害或功能障碍 疾病。鉴于科学研究机构的不断壮大，这一点很重要 有证据表明突触神经化学中的扰动是 与行为障碍和神经精神障碍有关。

The existence of environmental toxins that damage specific neurons raises the possibility that certain human neurodegenerative disorders may be of environmental origin. The development and application of simple and non- invasive methods that can assess alterations in brain neurochemistry would be an important step in studying population groups exposed to environmental neurotoxins. The overall objective of this project is to validate and assess the usefulness of a simple non-invasive coincidence detector system (dual- probe) for the measurement of neuronal markers using positron emitting radioligands. These studies of pre-synaptic and post-synaptic neuronal markers will be carried out in normal persons and experimental animal models as well as persons exposed to environmental or occupational neurotoxins. In persons chronically exposed to environmental toxins, these neurochemical measurements may be able to detect early signs of central nervous system damage or dysfunction prior to behavioral or clinical manifestation of disease. This is important in view of the growing body of scientific evidence which indicates that perturbations in synaptic neurochemistry are related to behavioral dysfunction and neuropsychiatric disorders.