Regulation of HIV-1 Gag expression by SR proteins

艾滋病毒感染导致艾滋病，是一种全球流行病。2010年，有270万新感染病例，180万人死于艾滋病，3400万人感染艾滋病毒。目前，已批准的抗逆转录病毒药物针对艾滋病毒生命周期的四个阶段，2010年有700多万人接受抗逆转录病毒治疗。然而，艾滋病毒的耐药菌株是一个重大问题，仍然需要新的药物靶点。开发新型抗病毒药物的一种很有希望的方法是靶向细胞蛋白。该提案将研究一个称为SR蛋白的细胞蛋白家族如何调节HIV结构蛋白Gag的表达，这是制造病毒粒子所必需的。我们将确定12种人类SR蛋白中的哪一种调节Gag表达，并从机制上描述它们是如何调节Gag表达的。这将确定哪些SR蛋白可以被抗逆转录病毒药物靶向抑制HIV Gag表达。

HIV infection causes AIDS and is a worldwide pandemic. In 2010, there were 2.7 million new infections, 1.8 million AIDS-related deaths, and 34 million people living with HIV. Currently, there are approved antiretroviral drugs targeting four stages of the HIV life cycle and in 2010 there were over 7 million people receiving antiretroviral therapy. However, drug resistant strains of HIV are a significant problem and there is still a great need for novel drug targets. One promising approach to develop new antiviral drugs is to target cellular proteins. This proposal will investigate how a family of cellular proteins, called SR proteins, regulate expression of the HIV structural protein Gag, which is necessary to make virions. We will identify which of the 12 human SR proteins regulate Gag expression and mechanistically characterise how they do so. This will identify which SR proteins could be targeted by antiretroviral drugs to inhibit HIV Gag expression.