PHYSICAL LAWS FOR BLOOD FLOW THROUGH SMALL NETWORKS

这项拟议研究的总体目标仍然是发展 和利用真实的血液流动数学网络模型 通过微循环系统。这些模型应预测本地(AS 以及总体)流动参数，例如血浆和细胞的通量 (尤其是红细胞)，以及这些变量对变化的反应 在血液的细胞成分(红细胞压积，白色)等参数中 细胞-红细胞比率等)、细胞变形性和壁粘性， 血管参数(直径、长度、横截面形状等)和 压力。然后，这些模型将用于预测当地 氧气和其他底物、代谢物的浓度和流量， 微循环血管中的血管活性物质、治疗药物等 邻近的组织。它们还将作为一种手段来扩展 一次可获得的有限数量的数据的有用性 体内实验，通过提供一个通用的框架，通过它 VIVO数据可以更全面地解释，以及内插和 推断出来的。 该项目将利用项目2中改变的血细胞来确定 细胞变形性和体积在血流调节中的作用 通过微血管网络，从而允许发展 包含细胞变形性和细胞体积的血流动力学关系 作为独立的参数。Project 4是以下项目的主要合作者 这一项目，为获得体内微循环提供了机会 用于测试血液动力学关系和计算机模拟模型的数据； 它也为我们提供了一个目前测试和改进的机会 用于确定体内流动参数的技术。这 合作将扩大，包括体内的计算机模拟 项目4中研究的流程。

The overall objective of this proposed research remains the development and utilization of realistic mathematical network models of blood flow through microcirculatory system. These models should predict the local (as well as overall) flow parameters, such as the fluxes of plasma and cells (especially erythrocytes), and the responses of these variables to changes in such parameters as cell composition of the blood (hematocrit, white cell-red cell ratio, etc.), cell deformabilities and wall adhesivenesses, vessel parameters (diameters, lengths, cross sectional shapes, etc.) and pressures. These models would then be useful in predicting local concentrations and fluxes of oxygen and other substrates, metabolites, vasoactive agents, therapeutic drugs, etc. in microcirculatory vessels and adjacent tissue. They would also serve as a means of extending the usefulness of the limited amount of data which can be obtained in a single in vivo experiment, by providing a general framework through which the in vivo data can be more fully interpreted, as well as interpolated and extrapolated. This project will utilize altered blood cells from Projects 2 to determine the roles of cell deformability and volume in regulating blood flow through microvascular network, thereby permitting development of hemodynamic relationships which contain cell deformability and cell volume as independent parameters. Project 4 has been a major collaborator with this project, providing an opportunity to obtain in vivo microcirculatory data for testing hemodynamic relationships and computer simulation models; it has also provided us with an opportunity to test and improve currently used techniques for determining in vivo flow parameters. This collaboration will be expanded, and include computer simulation of in vivo flows studied in Project 4.