Acellular Approaches for Therapeutic Delivery: UK Regenerative Medicine Platform Hub Application

再生医学将在未来30年改变人类健康。我们有能力创造新的治疗方法，修复受损的组织，使身体恢复到原来的健康状态。我们的中心将在这些治疗的发展中发挥作用，从而帮助建立一个强大的英国行业，在全球范围内产生影响。我们特别感兴趣的是这些新疗法对患者的治疗方法。将活细胞作为药物输送是困难的，因为这些细胞很脆弱，如果遇到不利条件，就不会形成组织。我们将发明方法，将细胞以最佳状态运送到身体的正确部位，以修复组织。我们的Hub将创造可用于未来大量医疗应用的新材料和新技术。在我们工作的第一阶段，我们将设计新的材料，重建干细胞形成组织的最佳条件。接下来，我们将与7个团队合作，他们直接参与将新的科学突破转化为新药。这些团队将测试我们的材料，并通过初步研究用于帕金森氏症、肝脏疾病、骨修复、皮肤伤口再生、软骨修复、食道癌治疗以及协助前十字韧带手术来改进他们的设计。我们正在与英国领先的行业合作，以确保我们的技术可以作为源自英国但治疗世界各地患者的新产品得到发展。

Regenerative medicine will transform human health over the next 30 years. We have the ability to create new treatments that repair damaged tissues and restore the body to its original health. Our Hub will play a role in the development of these treatments and thereby help to build a strong UK industry that makes a worldwide impact. We are particularly interested in the methods by which these new treatments are administered to patients. It is difficult to deliver a living cell as a medicine because these cells are fragile and will not form tissue if they experience adverse conditions. We will invent methods to deliver cells to the correct part of the body in an optimal state to repair tissue. Our Hub will create new materials and technologies that can be used in a very large number of future medical applications. In the first phase of our work we will design new materials that recreate the opitmal conditions for stem cells to form tissue. Next we will work with 7 teams who are directly involved in translating new scientific breakthroughs into new medicines. These teams will test our materials and help improve their design by initial studies of suitability for use in Parkinson's Disease, liver diseases, bone repair, skin wound regeneration, cartilage repair, treatments of oesophageal cancer and to assist in anterior cruciate ligament operations.We are working with leading UK industry to ensure that our technologies can be taken forward as new products that originate in the UK but treat patients across the World.