GENTAMICIN PHARMACOKINETICS IN THE NEONATE

本项目将使用一室药代动力学模型预测 新生儿中庆大霉素的峰值和谷值。 如果这项研究的结果 可以一致地关联特定的变量，如窒息或 呼吸窘迫综合征，与庆大霉素清除率的变化， 新生儿，它将允许制定更适当的 建议使用庆大霉素治疗，并将降低发病率 新生儿血液中有毒和低于治疗水平的水平。

This project will use a one compartment pharmacokinetic model to predict gentamicin peaks and troughs in neonates. If the results of this study can consistently correlate particular variables, such as asphyxia or respiratory distress syndrome, with changing gentamicin clearance in the neonate, it would allow the formulation of more appropriate recommendations for gentamicin therapy, and would decrease the incidence of both toxic and subtherapeutic blood levels in newborn babies.