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ETHNIC DIFFERENCES IN AN ALCOHOL METABOLIZING ENZYME

ETHNIC DIFFERENCES IN AN ALCOHOL METABOLIZING ENZYME
酒精代谢酶的种族差异
批准号:
5222011
负责人:
Sanjeev Arora
金额:
$0.0万
依托单位:
--
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至

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中文摘要
翻译
酒精中毒和与酒精有关的肝病的发生率很高 美洲原住民和墨西哥裔美国人高于高加索人。 P4502E1是一种特殊的酶,它是由于慢性诱导而产生的 乙醇摄入,在这种情况下,它可能占乙醇的80% 通行证。本研究的重点是确定P4502E1是否 与酒精相关的易感性的种族差异很重要 肝脏损伤。这将通过筛查来自 三个种群。
英文摘要
The incidence of alcoholism and alcohol-related liver disease is much higher in Native Americans and Mexican Americans than in Caucasians. P4502E1 is an enzyme distinguished due to its induction by chronic ethanol ingestion, in which case it may account for 80% of ethanol clearance. The focus of this study is to determine whether P4502E1 is important in ethnic differences in susceptibility to alcohol-related liver injury. This will be investigated by screening lymphocytes from three populations.
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