Regulating protein translation to protect from UV-induced damage

皮肤是保护我们身体免受外部环境伤害的屏障，但长期暴露在紫外线下会导致皮肤炎症、衰老和癌症。皮肤表皮的维持是由干细胞紧密平衡和控制的，干细胞在产生后代（分化）的同时不断维持其数量（自我更新）。皮肤干细胞在发育过程中形成，并在成年后保留，使身体能够替换、恢复和再生死亡、受损或患病的表皮细胞。我们的研究计划旨在：(1)分析表皮干细胞对紫外线照射下皮肤再生的特殊贡献；(2)确定促进细胞在紫外线损伤下存活的新的内在关键因素。我们的研究将提高我们目前对健康皮肤如何维持的理解，并将导致对再生医学特别是皮肤修复，衰老和癌症具有重要意义的新发现。

Skin is the barrier that protects our body against the external environment, but chronic exposure to ultraviolet (UV) light causes skin inflammation, aging and cancer. The maintenance of the skin epidermis is tightly balanced and controlled by stem cells that continuously maintain their population (self-renewal) while generating progeny (differentiation). Skin stem cells are established during development and are retained in adulthood allowing the body to replace, restore and regenerate dead, damaged or diseased epidermal cells. Our research plan is designed to (i) analyze the specific contribution of epidermal stem cell to regenerate UV-exposed skin and (ii) identify novel intrinsic key factors that promote cell survival in response to UV-damage. Our research will improve our current understanding of how a healthy skin is maintained and will lead to novel discoveries with important implications for regenerative medicine in particular for skin repair, aging and cancer.