ORIGINS OF EXAGGERATED FINGER FLEXION IN STROKE

中风引起的上肢瘫痪后，自发性 手指屈曲通常在数周后出现，然后增加。 循序渐进。这种屈曲妨碍康复，因为它干扰 手指运动的自愿控制。建议的主要目标是 研究是为了刻画补药的性质和可能的原因 通过施加扰动的屈曲姿势，希望 指导未来的研究以寻求补救措施。拟议中的实验试图 为了检验肌挛缩的相对贡献，静态 自发性屈指的高张力、痉挛状态，并进行测试 皮肤传入对这一姿势的影响。静态以及 在外在手指上施加恒速伸展。 通过旋转掌指关节产生的屈肌 一个连接在手指上的伺服马达。受试者的回答将是 根据扭矩、角度位置和肌电数据进行量化。这个 大脑对侧手部声调的位置依赖性 通过检查，将病变与同侧手的病变进行比较 在自愿放松状态下记录的扭矩值。速度 依赖性将通过拉伸反射的量化来分析。 一系列恒速位移的响应。检视 皮肤传入的影响，表面麻醉剂将是 施加在手指上，重复了拉伸方案。这些研究 应该让我们深入了解皮肤传入在 手指屈肌张力和伸肌无力的发展 中风后。

Following stroke-induced paresis of the upper extremity, spontaneous finger flexion often appears with weeks, and then increases progressively. This flexion hinders rehabilitation by interfering with voluntary control of finger motion. The primary goal of the proposed research is to characterize the tonic nature and the possible causation of the flexion posture through imposed perturbations, in the hope of directing future research for remedies. The proposed experiments seek to examine the relative contributions of contracture, static hypertonicity, and spasticity to spontaneous finger flexion, and to test the effects of cutaneous afferents on this posture. Static as well as constant-velocity stretches would be imposed on the extrinsic finger flexors by rotation of the metacarpophalangeal joints, as produced by a servomotor coupled to the fingers. Subject response would be quantified in terms of torque, angular position, and EMG data. The position dependence of tone seen in the hand contralateral to the brain lesion would be compared with that of the ipsilateral hand by examining torque values recorded in the voluntarily relaxed state. Velocity dependence would be analyzed through quantification of stretch reflex responses for a series of constant-velocity displacements. To examine the effects of the cutaneous afferents, a topical anesthetic would be applied to the fingers and the stretch protocol repeated. These studies should provide insight into the role of the cutaneous afferents in the development of flexor tone and extensor weakness in the fingers following stroke.