BEHAVIORAL, ERP AND EEG ASYMMETRY IN AFFECTIVE DISORDERS

描述(改编自申请者摘要)：远景目标 是为了澄清异常知觉和电生理的性质 情感障碍中的不对称性，并评估大脑的价值 预测抗抑郁药物治疗结果的非对称性措施。 具体目标是：1)评估一个三因素模型，在该模型中， 一般的负面情绪、焦虑性唤醒和快感缺乏被认为是 与特定的大脑区域不对称有关；2)比较不对称 单独患有抑郁障碍，单独患有焦虑症的患者， 或者两者都有；3)测试焦虑唤醒是 与右顶颞区激活有关；4)评估预测 非享乐性与非享乐性脑局部不对称性的差异 抑郁症的亚组；5)对大样本患者进行测试 电生理学措施以评估预测的差异 治疗有效和无效之间的半球不对称 子组。 总共200名未服用药物的患者和40名正常对照将在 一组行为偏侧，静息脑电(EEG)， 认知事件相关电位(ERP)在三项研究中进行了测量。 研究1采用2×2设计比较仅患有MDD的患者，并 仅焦虑症(恐慌症或社交恐惧症)或两者都有，正常 控制。受试者还会接受皮肤电刺激和心理测试。 焦虑唤醒的衡量标准。研究2比较了无享乐性和非享乐性的亚群 在自我报告的基础上形成的非享乐性抑郁，结构化 对愉悦刺激反应的评估，以及“以访谈为基础” 诊断。研究3比较了抗抑郁药应答者和无应答者 行为和电生理测试，以及评估 快感缺乏症。这些研究应有助于确定 抑郁症的亚型和特征性的局部脑不对称和 具有独特的临床特征。

DESCRIPTION (Adapted from applicant's abstract): The long range objectives are to clarify the nature of abnormal perceptual and electrophysiologic asymmetries in affective disorders, and to assess the value of brain asymmetry measures for predicting outcome of antidepressant treatment. Specific aims are: 1) to evaluate a three-factor model in which symptoms of general negative affect, anxious arousal and anhedonia are hypothesized to be related to specific regional brain asymmetries; 2) to compare asymmetries of patients having a depressive disorder alone, an anxiety disorder alone, or both disorders; 3) to test the prediction that anxious arousal is associated with right parietotemporal activation; 4) to evaluate predicted differences in regional brain asymmetries between anhedonic and nonanhedonic subgroups of depression; 5) to test a large sample of patients on electrophysiologic measures so as to evaluate predicted differences in hemispheric asymmetries between treatment responsive and nonresponsive subgroups. A total of 200 unmedicated patients and 40 normal controls will be tested on a battery of behavioral laterality, resting electroencephalography (EEG), and cognitive event-related potential (ERP) measures in three studies. Study 1 uses a 2 X 2 design to compare patients having a MDD only, an anxiety disorder only (panic or social phobia) or both disorders, and normal controls. Subjects are also tested on electrodermal and psychometric measures of anxious arousal. Study 2 compares subgroups of anhedonic and nonanhedonic depression formed on the basis of self-reports, structured assessments of responses to pleasurable stimuli, and "interview-based" diagnoses. Study 3 compares antidepressant responders and nonresponders on the behavioral and electrophysiologic tests, as well as on the assessments of anhedonia. These studies should contribute to the identification of subtypes of depression and characteristic regional brain asymmetries and distinctive clinical features.