CENTER FOR MOLECULAR PHARMACOLOGY AND TOXICOLOGY

分子药理学和毒理学是在药理学、分子和细胞生物学以及医学之间迅速扩展的跨学科研究领域。这一领域的研究有望对基本的细胞调控过程以及药物、激素、毒素和环境化学物质影响细胞功能的机制有新的理解。这一新信息将对开发合理设计的新一代疗法至关重要，这种疗法可以在没有毒副作用的情况下中断疾病进程。该提案要求支持在华盛顿大学医学院药理学系建立分子药理学和毒理学中心。1950年设计的约4776平方英尺的过时研究空间将被拆除并重新开发，以满足当前和未来的研究需要。此外，1950年建造的大约3679平方英尺的研究空间将在不进行重大拆除的情况下更新到目前的研究标准。该中心将根据目前的研究标准提供现代研究，而不会进行重大拆除。该中心将为一个由8名科学家组成的核心学院提供现代化的研究设施，提供分子神经生物学和神经药理学、心血管调节和药理学的分子方面以及分子毒理学方面的互动研究项目。另外10个附属学院也将参加该中心的研究和研究培训计划。这些教师的博士前研究培训将导致获得药理学、分子和细胞生物学以及神经生物学和行为学的博士学位。博士后研究培训将为年轻科学家提供在分子药理学和毒理学领域取得成功所必需的跨学科知识和现代研究工具。根据这一倡议开发的新设施将对华盛顿大学分子药理学和毒理学的研究和研究培训产生重大影响。

Molecular Pharmacology and Toxicology is a rapidly expanding interdisciplinary area of research at the interface between pharmacology, molecular and cellular biology, and medicine. Research in this area promises new understanding of fundamental cellular regulatory processes and the mechanisms by which drugs, hormones, toxins and environmental chemicals affect cellular function. This new information will be essential to development of a new generation of therapeutics designed rationally to interrupt disease processes without toxic side effects. This proposal requests support for establishment of a Center for Molecular Pharmacology and Toxicology in the Department of Pharmacology at the University of Washington School of Medicine. Approximately 4,776 square feet of outdated research space designed in 1950 will be demolished and re-developed for current and future research needs. In addition, approximately 3,679 square feet of research space build in 1950 will be updated to current research standards without major demolition. The Center will provide modern research to current research standards without major demolition. The Center will provide modern research facilities for a Core Faculty of eight scientists with interactive research programs in molecular neurobiology and neuropharmacology, molecular aspects of cardiovascular regulation and pharmacology, and molecular toxicology. An additional 10 Affiliate Faculty will also participate in the research and research training programs of the Center. Predoctoral research training by these faculty will lead to Ph.D. degrees in Pharmacology, Molecular & Cellular Biology, and Neurobiology & Behavior. Postdoctoral research training will provide young scientists with the interdisciplinary knowledge and modern research tools necessary for a successful career in Molecular Pharmacology and Toxicology. The new facilities developed under this initiative will have a major impact on research and research training in Molecular Pharmacology and Toxicology at the University of Washington.