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REGULATION OF FGF EXPRESSION DURING RETINAL DETACHMENT

REGULATION OF FGF EXPRESSION DURING RETINAL DETACHMENT
视网膜脱离过程中 FGF 表达的调节
批准号：
2888226
负责人：
Leonard Martin Hjelmeland
金额：
$30.68万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
1986
资助国家：
美国
项目状态：
已结题
起止时间：
1986-07-01 至 2000-06-30
来源：
https://reporter.nih.gov/project-details/2888226
关键词：
apical membrane basement membrane cats cell adhesion cell adhesion molecules cell cycle cellular polarity confocal scanning microscopy fibroblast growth factor gene expression genetic regulation growth factor receptors human tissue immunocytochemistry in situ hybridization pathologic process phosphorylation protein tyrosine kinase proteoglycan receptor binding retina detachment retinal pigment epithelium western blottings

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中文摘要
翻译
描述：（改编自申请人摘要）RPE扮演了一个
英文摘要
DESCRIPTION: (Adapted from applicant's abstract) The RPE plays a critical role in maintaining the viability of retinal neurons. This grant tests the hypothesis that FGFs and their receptors are segregated on the apical and basal surfaces of the RPE cells, and that loss of this polarization results in their proliferation. There are three specific aims, each with individual objectives. First, is the release of individual FGFs polarized in monolayers of human RPE in vitro. Second, are the distribution of high and low affinity FGF receptors polarized in human RPE monolayers. Third, do cell adhesion molecules regulate basic FGF gene expression.
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    UNIVERSITY OF CALIFORNIA AT DAVIS
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  • 依托单位：
    UNIVERSITY OF CALIFORNIA AT DAVIS
Epigenetic regulation of SOD2 and CFH gene expression in the aging RPE
  • 批准号：
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  • 项目类别：
  • 资助金额：
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  • 财政年份：
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  • 负责人：
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  • 依托单位：
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EPIGENETIC AGING OF THE OXIDATIVE STRESS RESPONSE IN THE MOUSE RPE
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  • 项目类别：
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  • 财政年份：
    2010
  • 负责人：
    Leonard Martin Hjelmeland
  • 依托单位：
    UNIVERSITY OF CALIFORNIA AT DAVIS
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