ADVANCED STATISTICAL TECHNIQUES FOR PREVENTION RESEARCH

为了了解如何预防吸毒的复杂性 干预措施可能在青少年中奏效，更复杂的统计学 技术将是必需的。已提出四个相关项目，以 在预防研究中提供更广泛的方法论视角， 特别是在干预效果评价中：(1)应用 回归模型和结构方程的多样本方法 更充分地评估青少年干预效果的模型 物质使用行为；(2)模型的应用 用发育发育来评价青少年的预防效果 物质使用的进展；(3)多水平模型在 调查学校环境对青少年物质使用的影响； 以及(4)调查参与者流失的影响 预防研究。蒙特卡洛(计算机模拟)研究和 将进行实证研究，以调查这些措施的表现 应用于预防研究的模型，特别是在预防研究领域 对预防方案的评估。 申请人的支持机构是卫生研究所 促进和疾病预防研究(IPR)，隶属于 南方大学医学院预防医学 加利福尼亚。知识产权的主要目标是预防疾病。至 为了实现这一目标，该研究所拥有广泛的研究组合 旨在促进儿童和儿童初级预防的议定书 青少年。知识产权研究侧重于多组成部分、综合性 社区预防方法。知识产权开发中西部 预防计划(MPP)，这是一项以学校为本的药物使用预防 针对中西部两个城市的青少年的项目。纵向的 从MPP获得的数据将提供给申请人进行 对拟议的高级统计方法的评价和实证检验 方法：研究方法。

In order to understand the complexity of how drug use prevention interventions may work among adolescents, more sophisticated statistical techniques will be needed. Four relevant projects have been proposed to offer broader methodological perspectives in prevention research, especially in the evaluation of intervention effects: (1) Application of the multi-sample approach with regression models and structural equation models to more adequately evaluate intervention effects on adolescents' substance use behavior; (2) Application of models incorporating developmental growth to evaluate prevention effects with adolescents' progression in substance use; (3) Application of multilevel models to investigate the impacts of school context on adolescents' substance use; and (4) Investigation of the impacts of participant attrition in prevention research. Monte Carlo (computer simulation) study and empirical study will be conducted to investigate the performance of these models applied to prevention research, particularly in the area of evaluation of prevention programs. The applicant's supporting institution is the Institute of Health Promotion and Disease Prevention Research (IPR), within the Department of Preventive Medicine, School of Medicine, University of Southern California. The principal goal of IPR is the prevention of disease. To accomplish this goal, the institute has an extensive portfolio of research protocols designed to promote primary prevention among children and adolescents. IPR research focuses on multi-component, comprehensive community approaches to prevention. IPR developed the Midwestern Prevention Project (MPP), which is a school-based substance use prevention project targeting adolescents in two Midwestern cities. The longitudinal data obtained from MPP will be made available to the applicant to perform evaluation and empirical testing of the proposed advanced statistical methods.