CONTROL OF RESPIRATORY MOTOR ACTIVITY--ALPHA 2 RECEPTORS

这项研究的长期目标是研究α2的作用-- 控制呼吸运动输出和呼吸的肾上腺素能受体 节奏。这项研究的主要目标是确定 其中α2-肾上腺素能受体调节呼吸节律，表现为 延髓和脊髓运动神经元的传出活动变化 特定的呼吸肌。实现这一目标的具体目标 求婚，清醒站立的山羊模型和氯醛糖麻醉的山羊模型， 将使用人工呼吸的山羊模型来测试特定的 与α2肾上腺素受体控制呼吸运动有关的假说。 α-2激动剂(可乐定或呋喃苯肼)可引起呼吸性心律失常 在清醒的山羊中，存在交替的呼吸急促 和呼吸抑制。在麻醉动物的双侧 迷走神经切断术和去除外周化学感受器的α2激动剂诱导 长时间的和可变的呼吸暂停。拟议研究的具体目标 L)考察了迷走神经反馈在孤独症发生发展中的作用 α2-肾上腺素能受体激动剂引起的呼吸不稳定；2)试验 α2-肾上腺素能受体不同地控制颅脑的假说 和脊髓运动神经元活动；3)检查中枢和 运动神经元的外周(颈动脉体)化学感觉机制 激活及其与α2肾上腺素受体的相互作用。阿尔法-2 受体激动剂作为气体麻醉、止痛、 镇静和抗高血压药物；然而，几乎没有 关于这些物质对呼吸的影响的现有信息 神经调节药物。通过拟议的研究获得的数据将 提供重要信息，说明我们对 α2肾上腺素受体在临床上的意义越来越大 呼吸生理学。

The long term objectives of this study are to examine the role of alpha2- adrenoceptors in the control respiratory motor output and respiratory rhythm. The principal objective of the study is to determine the extent to which alpha2-adrenoceptors modulate respiratory rhythm, manifested as changes of efferent activity from medullary and spinal motoneurons to specific respiratory muscles. To carry out the specific aims of this proposal, the awake, standing goat model and the chloralose-anesthetized, artificially-ventilated goat model will be used to test specific hypotheses related to respiratory motor control by alpha2 adrenoceptors. Alpha-2 agonists (clonidine or guanabenz) induce respiratory arrhythmias in awake goats consisting of alternating periods of tachypneic breathing and respiratory depression. In anesthetized animals with bilateral vagotomy and peripheral chemoreceptors removed alpha2 agonists induce prolonged and variable apneas. The specific aims of the proposed research are to, l) examine the role of vagal feedback in the development of breathing instabilities induced by alpha2-adrenoceptor agonists; 2) test the hypothesis that alpha2-adrenoceptors differentially control cranial and spinal motoneuronal activity; 3) examine the effects of central and peripheral (carotid body) chemosensory mechanisms on motoneuronal activation and their interactions with alpha2 adrenoceptors. Alpha-2 receptor agonists are important as adjuncts to gas anesthesia, analgesia, sedation and anti-hypertensive agents; however, there is little information available concerning the respiratory effects of these neuromodulating drugs. The data obtained by the proposed research will provide important information regarding our knowledge of the role of alpha2 adrenoceptors that have growing clinical significance in respiratory physiology.