Centre for Integrated research into Musculoskeletal Ageing (CIMA) Renewal

MRC-关节炎研究英国肌肉骨骼老化综合研究中心(CIMA)是一个独特的团队。CIMA从利物浦、纽卡斯尔和谢菲尔德这三所英国主要大学引进了多种技能。它帮助医生和实验室科学家一起工作，以掌握：1)我们的肌肉、骨骼和关节随着年龄的增长是如何变化的。2)这如何让一些人容易出现关节炎和骨质疏松症等这些组织的问题。3)每个人都能做些什么来降低出现这些问题的风险。因此，FarCIMA在2012年首次获得为期5年的资金支持。随着年龄的增长，CIMA在弄清肌肉、骨骼和关节的一些关键过程方面取得了很大进展。除了找出可能降低这些问题的风险的方法外，我们还对一些可能的营养剂进行了试验。这些可能会减少与年龄相关的肌肉、骨骼和关节的衰退。我们已经获得了一些早期证据，表明增加维生素D可能有助于减少与年龄相关的衰退，但增加硝酸盐摄入量可能没有帮助。在这一重要领域扩大研究的一大限制也是缺乏训练有素的研究人员和医生。因此，该中心还开发并运营了良好的培训课程来满足这一需求。未来：目标、治疗和培训此次竞标是为了从医学研究理事会(MRC)和英国关节炎研究中心获得更多5年的资金，以帮助这项工作的发展。我们的第一阶段资金让CIMA成员发现了细胞的某些变化--称为表观遗传变化。这些似乎对影响肌肉、骨骼和关节组织随着年龄的增长是快速还是缓慢衰退至关重要。我们计划在利物浦、纽卡斯尔和谢菲尔德开展一个关联研究项目。这将寻求解决这些变化的重要性，以及我们是否可以修改这些变化来降低肌肉、骨骼和关节问题的风险。我们还将共同努力，更密切地研究营养和运动是否可以预防或降低这些问题的风险。我们还计划扩大我们的培训计划，以便更多的基础科学家和医生能够对这些问题进行出色的研究。关键成果将在论文和会议中分享。将进行更多的资金竞标来完成这项工作。关节炎患者帮助塑造了这一竞标。例如，通过参加一系列“关节炎很重要”的公共参与活动。这些帮助公众掌握了CIMA的研究，并确定了未来的优先事项。最重要的是，这包括掌握新的关节炎治疗方法，以及研究结果如何使患者受益。我们还要求一组15名患者就最终的分层总结提出建议。我们认为，经常与患者谈论研究并听取他们的意见有助于更好的研究。更好地参与，患者和公众将继续积极参与，以各种方式提供见解和宝贵的反馈。面对面的会议仍将是一个关键部分。将使用更多的活动，包括地方、国家和全球计划。将与学校开展新的合作，分享CIMA的工作，启发新想法，培养人才。北部语音数字平台将在整个中心和更广泛的范围内支持这一点。CIMA的网站也将保持最新，并在Twitter上分享进展。我们知道大多数老年人还没有使用这些设备，但随着使用变得更容易和更便宜，这种情况可能会迅速改变。我们希望年轻人能帮助解决这个问题。我们还将加强与制药公司、地方当局和国民健康保险制度的合作。这将使我们能够开发方法，确保我们的发现迅速付诸实践，使老年人受益。关节炎也是由纽卡斯尔大学领导的NIHR詹姆斯·林德联盟关于老龄化和多种疾病的优先设定伙伴关系中包括的一系列关键疾病之一。这将为患有关节炎的患者提供更多参与并链接到CIMA的机会。

OverviewThe MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing (CIMA) is a unique team. CIMA brings in a mix of skills from three major U.K. Universities: Liverpool, Newcastle and Sheffield. It helps doctors and lab scientists to work together to grasp: 1) How our muscles, bones and joints change as we age. 2) How this makes some people prone to problems with these tissues such as arthritis and osteoporosis. 3) What each person can do to reduce the risk of developing these problems. Progress So FarCIMA was first funded for 5 years in 2012. CIMA has made great progress in figuring out some key processes in muscles, bones and joints as we age. As well as working out what might reduce the risk of developing these problems, we have also done trials of some likely nutritional agents. These might reduce age-related decline in muscles, bones and joints. We have obtained some early evidence that raising vitamin D may help reduce age-related decline, but putting up nitrate intake may not help. A big limit to expanding research in this important area has also been a lack of well-trained researchers and doctors. So the Centre has also developed and run good training courses to meet this need.Future: Targets, Treatments & TrainingThis bid is for 5 more years of funding from the Medical Research Council (MRC) and Arthritis Research UK to help build on this work. Our first phase of funding has let the CIMA members spot certain changes to cells- called epigenetic changes. These seem vital in influencing whether muscles, bones and joint tissues decline quickly or slowly as we age. We plan to do a linked research programme across Liverpool, Newcastle and Sheffield. This will seek to work out the importance of these changes and whether we can modify the changes to reduce the risk of getting muscle, bone and joint problems. We will also work together to look more closely at whether nutrition and exercise can prevent or reduce the risk of these problems. We also plan to expand our training programme so more basic scientists and doctors can do excellent research into these problems. Key results will be shared in papers and meetings. More funding bids will be made to do this work.Patient ViewPeople with arthritis have helped to shape this bid. By joining a series of "Arthritis Matters" Public Engagement events, for example. These have helped the public grasp CIMA's research and shape future priorities. Above all this includes a grasp of new arthritis treatments and how study findings can benefit patients. We also asked a group of 15 patients to advise on the final lay summary. We think talking to patients often about research and listening to their views makes for better research.Better EngagementGoing forward, patients and the public will continue to be actively involved by providing insight and valued feedback in many ways. Face to face meetings will remain a key part. And more events will be used, including local, national and global schemes. There will be new work with schools, to share CIMA's work, inspire new ideas and nurture talent. The VOICE North digital platform will support this across the Centre and more widely. The CIMA website will also be kept up to date and advances shared on Twitter. We know most older people don't use these yet, but that could change quickly as access gets easier and cheaper. We expect young people to help make solutions for this. We will also increase our work with drug companies, local authorities and the NHS. This will allow us to develop ways to make sure our findings are quickly put into practice to benefit older people. Arthritis is also one of a key number of conditions included in the NIHR James Lind Alliance Priority Setting Partnership on Ageing and Multiple conditions, led by Newcastle University. This will provide more chances for patients who have arthritis to be involved and link to CIMA.