NON INVASIVE MRI OF HUMAN VULNERABLE PLAQUE

易损斑块容易破裂，并可导致急性冠状动脉 综合症。这3个协作项目的目标是确定 弱势群体形成和稳定的相关机制 并开发非侵入性方法检测和检测斑块 人物刻画。该项目将通过以下方式来表征易受攻击的斑块 人类的核磁共振成像。在目标1中，无症状的血脂异常患者和 将对中风患者进行胸主动脉斑块筛查 和颈动脉。血脂水平将通过治疗得到改善 使用他汀类药物或他汀类药物加烟酸(以提高高密度脂蛋白)和斑块的变化 大小和成分将连续进行核磁共振检查。在目标2中，一个 将利用猪的人类冠状动脉疾病模型来开发 核磁共振技术检测和表征冠状动脉斑块，然后这些 这些技术将应用于人类。总体而言，这些项目代表 经验丰富的调查人员高度互动的努力，他们将制定 利用分子生物学、动物实验研究易损斑块的新方法 模型、临床研究和核磁共振。

Vulnerable plaques are prone to rupture and can cause acute coronary syndromes. The goal of these 3 collaborative projects are to identify the mechanisms related to the formation and stabilization of vulnerable plaques and to develop non-invasive methods for their detection and characterization. This project will characterize vulnerable plaques by MRI in humans. In aim 1, asymptomatic patients with dyslipidemia and patients with stroke will be screened for plaques in the thoracic aorta and carotid arteries. Plasma lipid levels will be modified by therapy with a statin or statin plus niacin (to raise HDL) and changes in plaque size and composition will be followed serially by MRI. In aim 2, a porcine model of human coronary artery disease will be used to develop MRI techniques to detect and characterize coronary plaques, then these techniques will be applied to humans. Overall, the projects represent highly interactive efforts of experienced investigators who will develop new approaches to the vulnerable plaque using molecular biology, animal models, clinical investigation, and MRI.