Development of Antimalarial Drug Leads Through Inhibition of Food Vacuole Falcipains

疟疾是一种在全世界造成巨大发病率和死亡率的传染病。据估计，每年有近100万人死于疟疾，几乎都是由于感染恶性疟原虫，这是最致命的人类疟疾寄生虫。寄生虫对目前处方药物的耐药性的出现导致迫切需要开发具有新作用模式的新抗疟药。该项目将发现新的抗疟药物，通过阻止宿主血红蛋白的消化来饿死寄生虫。

Malaria is an infectious disease responsible for enormous morbidity and mortality worldwide. It is estimated to account for nearly one million deaths annually, nearly all due to infection with Plasmodium falciparum, the most virulent human malaria parasite. The emergence of parasites resistant to currently prescribed drugs has resulted in a desperate need for the development of new antimalarials with novel modes of action. This project will discover new antimalarials that starve the parasite by preventing the digestion of host hemoglobin.