CANCER RISK AND MARIJUANA USE

描述：(申请人描述)我们建议试点和发展 利用临床数据研究大麻对健康影响的研究 使用。具体来说，我们将评估研究癌症风险的可行性。 根据已经收集到的关于大麻使用的信息 通常来自进入罗斯威尔公园癌症研究所(RPCI)的患者，自 1982年。这些数据需要与医疗记录和肿瘤登记相匹配 数据、对答复率和完整性的评价以及按以下方式分类 疾病和患者出生队列和性别。我们将评估以下项目的效用 这些数据用于病例对照研究，目的是复制最近 其他人报告某些癌症类型在某些患者中的风险为 以及存在或不存在其他地点的风险。首字母 调查将集中在前列腺癌和宫颈癌上。后续 研究将检查对其他主要肿瘤类型的影响，包括肺， 结直肠癌、卵巢癌和乳腺癌。为了更好地了解交互 我们将检查癌症高危患者的危险因素和暴露情况 在所研究的整个人群中暴露变量之间的相关性。 我们还将对数据进行质量控制评估，以确定 通过我们的方法收集的大麻暴露数据的重复性 已经雇佣了。一旦完成了这些发展步骤，这 分析数据库可用于探索新的假设、验证 其他人的发现，并检查迄今未见的风险相互作用 有可能。它也有可能成为未来的基础 将生物和/或分子标记与 已定义的流行病学来源。因为儿童的发育特性 活动与主办方及赞助机构的有限优先权 在药物滥用研究方面的经验，这是在小申请下提出的 助学金计划。

DESCRIPTION: (Applicant's Description) We propose pilot and developmental studies on the use of clinical data to study the health effects of marijuana use. Specifically, we will assess the feasibility of studying cancer risk based upon information regarding marijuana use that have been collected routinely from patients entering Roswell Park Cancer Institute (RPCI) since 1982. These data require matching to medical record and tumor registry data, evaluation of response rates and completeness, and classification by disease and patient birth cohort and sex. We will evaluate the utility of these data for case-control studies for the purposes of replicating recent reports by others of risk for certain cancer types in certain patients as well as the presence or absence of risk for other sites. Initial investigation will focus on prostate and cervical cancer. Subsequent studies will examine effects in other major tumor types including lung, colorectal, ovary and breast cancers. To better understand the interaction of risk factors and exposures in patients at risk of cancer we will examine correlation among exposure variables across the entire population studied. We also will conduct quality control assessments of the data to determine the reproducibility of marijuana exposure data collected by the means we have employed. Once these developmental steps are accomplished, this analytic database can be used to explore new hypotheses, validate the findings of others, and examine interactions of risks not heretofore possible. It is also possible that it can be the basis for future multidisciplinary efforts that link biological and/or molecular markers to the defined epidemiologic resource. Because of the developmental nature of the activities and the PI and sponsoring institution's limited prior experience in drug abuse research, this application is made under the Small Grants Program.