Escherichia coli ST131: a model for high-risk transmission dynamics of antimicrobial resistance

本项目将连接大量的跨国学术资源，调查大肠杆菌ST 131克隆的传播成功。E.大肠杆菌是全球泌尿道和血液感染的最常见原因。世卫组织最近的一份报告指出，对最广泛使用的抗生素类别之一（氟喹诺酮类[FQs]）的耐药性非常普遍。在世界上许多地方，FQs现在对一半以上的患者无效。一个E大肠杆菌克隆ST 131是导致这种全球性头孢菌素-R和头孢菌素-R大流行的主要原因，每年造成数百万耐药感染。目前尚不清楚ST 131的哪些特征导致了21世纪最大的抗生素耐药性成功。我们提出了一个欧洲-加拿大联合财团，将调查ST 131的传输动力学。这项研究将探讨抗性和毒力基因的垂直和水平传播，以及它们如何促成ST 131在人类、动物和不同环境中的传播成功。广泛的目标是通过更好地了解管理由于多重耐药E。杆菌该研究将探讨ST 131的高传播率和成功的原因。史蒂芬·霍金曾说过：“智能是适应变化的能力。ST 131迅速适应环境变化;我们需要知道为什么和如何。该项目将作为一个模型，预测随着细菌中多药耐药克隆的不断出现，未来可能发生的情况。

This project will connect a large number of transnational academic resources to investigate the transmission success of the Escherichia coli ST131 clone. E. coli is the most common cause of urinary tract and bloodstream infections worldwide. A recent WHO report states that resistance to one of the most widely used antibiotic classes (fluoroquinolones [FQs]) is very widespread. In many parts of the world, FQs are now ineffective in more than half of patients. A single E. coli clone, ST131, is predominantly responsible for this global FQ-R and cephalosporin-R pandemic causing millions of antibiotic-resistant infections annually. It remains unclear which features of ST131 had resulted in the biggest antimicrobial resistance succes of the 2000s. We propose a combined European-Canadian consortium that will investigate the transmission dynamics of ST131. This study will explore the vertical and horizontal transmission of resistance and virulence genes and how they contributed to the transmission success of ST131 among humans, animals and different environments. The broad goal is to improve human health by better understanding managing infections due to multidrug resistant E. coli. The study will explore explanations for the high transmission rates and success of ST131. A famous quote from Stephen Hawking; "Intelligence is the ability to adapt to change". ST131 adapted rapidly to environmental changes; we need to know why and how. This project will serve as a model to predict what can possibly happen in the future with the continuing emergence of multidrug resistant clones among bacteria.